Propylamine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable well documented publication which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

observation period: 7 days

Principles of method if other than guideline:

BASF-Test, see details in remarks on material and methods.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propylamine

EC Number:

203-462-3

EC Name:

Propylamine

Cas Number:

107-10-8

Molecular formula:

C3H9N

IUPAC Name:

propan-1-amine

Details on test material:

- Name of test material (as cited in study report): n-Propylamin
- Analytical purity: > 99.5 %

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

yes

Remarks:

Gas chromatography

Duration of exposure:

4 h

Concentrations:

12.0, 7.27, 4.6, 2.84 mg/l analytical value (nominal: 15.9, 14.2, 7.8, 6.4 mg/l)

No. of animals per sex per dose:

10

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: before start of the study, on days 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LC50

Effect level:

7.06 mg/L air

Exp. duration:

4 h

Effect levels 2

Sex:

male

Dose descriptor:

LC50

Effect level:

6.32 mg/L air

Exp. duration:

4 h

Effect levels 3

Sex:

female

Dose descriptor:

LC50

Effect level:

7.87 mg/L air

Exp. duration:

4 h

Mortality:

12 mg/l: 4 males and 8 females died within 24 h, 2 males and 2 females within 48h, 2 males within 72h, 1 male within 4 days and 1 male on day 9.
7.27 mg/l: 3 males and 2 females died within 24 h, 1 male within 48 h and 1 male on day 7.

Clinical signs:

other: Eye lids closed, watery to reddish eye and nose secretion, salivation, wiping of the snouts, dyspnoea, swollen eyes, nebula, corrosions at nose and eyes, clouded cornea, apathy, crouched position, rough and sticky coat, tremor and staggering walk, bad gen

Body weight:

Initially weight loss at 12 mg/l, 7.27 mg/l and 4.6 mg/l.

Gross pathology:

Animals that died:
Heart: acute dilatation (right), acute congestion;
Lung: infarctoic congestion partially accompanied by lung edema, effusion of blood in the thorax; trachea: partially mucosal bleeding in the cranial region,
Swelling of the anogenital region (except rectum), cachexia

Sacrificed animals: no abnormalities.

Any other information on results incl. tables

Mortality:

Concentration (mg/l)	male	female
12.0	10/10	10/10
7.27	5/10	2/10
4.6	3/10	1/10
2.84	0/10	0/10

Weight:

Dose (mg/l)	Gender	0 h	7 days	14 days
12.0	male	183	118	-
	female	176	-	-
7.27	male	191	182	219
	female	180	160	176
4.6	male	190	183	221
	female	188	170	191
2.84	male	182	201	237
	female	178	182	205
control	male	179	233	278
	female	175	199	210

The test substance caused systemic toxicity (including mortality) and local irritation in a dose dependent manner.