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EC number: 211-105-8
CAS number: 629-73-2
In an acute toxicity study, eight homologous
series of n-alkenes (n-olefins), including 1-hexene, were evaluated for
their potential to cause acute toxicity using an aspiration
process. Groups of 5 anesthetized male albino Wistar rats were either
administered 0.2 millilitre or 1 millilitre of liquid or aerosolized
test material respectively into the mouth. When breathing resumed and
was regular after test material administration, the animals’ nostrils
were closed with fingers during the end of expiration phase to promote
aspiration of the test material. This process was repeated until all of
the test material had been aspirated. After dosing, animals were
observed for a minimum of 4 hours at intervals ranging from 5 to 30
minutes. Animals that survived for 24 hours were sacrificed and lungs
were weighed and received gross necropsy.
Three rats receiving 1 -hexene died within
24 hours. Additionally, rats dosed with 1 -hexeneexhibited central
nervous system effects.Lung weights of these animals did not differ
significantly form control animals.Study authors reported that grossly,
pathologically, lungs of these animals displayed typical "liver-like
A quantitative estimate of acute toxicity
was not reported for this study.Based on the study outcome, the study
authors concluded that 1-hexene is toxic when aspirated causing rapid
death in 3 of the five treated animals. Two of the live animals
reportedly did not aspirate any test material since 1-hexene "boiled out
of the mouth" before it was aspirated.
This study received a Klimisch score of 2
and is classified as “reliable with restrictions”because although the
study was well conducted, there is no statement regarding whether this
study was conducted according to GLP or equivalent.
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