Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-233-8 | CAS number: 104-75-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 948
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: list III.
- Author:
- Smyth, H.F. et al.
- Year:
- 1 949
- Bibliographic source:
- J. Ind. Hyg. Toxicol. 31, 60-62
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- see details in remarks on material and methods.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhexylamine
- EC Number:
- 203-233-8
- EC Name:
- 2-ethylhexylamine
- Cas Number:
- 104-75-6
- Molecular formula:
- C8H19N
- IUPAC Name:
- 2-ethylhexylamine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- other: acetone
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.01 mL
- Concentration: undiluted or as 10% dilution in acetone - Duration of treatment / exposure:
- 4 h or 24 h
- Observation period:
- 24 h
- Number of animals:
- 5
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 6
- Max. score:
- 10
- Reversibility:
- no data
Any other information on results incl. tables
In a vesicant test the undiluted compound produced necrosis on 4 of 5 rabbits, but irritation was practically nil with a 10% dilution in acetone. A 4 h rabbit belly irritation test also indicated the production of necroses of the skin.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
