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EC number: 304-990-8 | CAS number: 94313-91-4
2 - Well-defined erythema
2 - Slight oedema (edges of area well-defined by definite raising)
1 - Very slight oedema (barely perceptible)
The acute dermal toxicity of CAS#10595 -49 -0 was assessed in the Wistar strain rat. The method was designed to be compatible with OECD 402 and Method B3 Acute Toxicity (Dermal) of EC No. 440/2008.
A group of ten animals (five males and five females) was given a single, 24 hour, semi-occluded dermal application of the undiluted test item to intact skin at a dose level of 2000 mg/kg bodyweight. Clinical signs and bodyweight development were monitored during the study. All animals were subjected to gross necropsy.
There were no deaths. There were no signs of systemic toxicity. Signs of dermal irritation noted were very slight to well-defined erythema, very slight to slight oedema, haemorrhage of dermal capillaries, blanching of the skin, light brown discolouration of the epidermis, loss of skin elasticity, crust formation, small superficial scattered scabs and scab lifting to reveal dried blood or glossy skin.
Animals showed expected gains in bodyweight, except for one female which showed bodyweight loss during the first week but expected gain in bodyweight during the second week. No abnormalities were noted at necropsy.
The acute dermal median lethal dose (LD50) of the test item in the Wistar strain rat was found to be greater than 2000 mg/kg bodyweight.
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