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EC number: 266-797-4 | CAS number: 67633-96-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral (OECD TG 401): > 5000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 May 1979 - 30 July 1979
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Remarks:
- The study was done in a GLP lab.
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Inc., Wilmington, Massachusetts.
- Weight at study initiation: males: 185 to 210g; females: 172 to 187g
- Fasting period before study: Overnight until one hour after dosing.
- Housing: Individually housed in suspended stainless steel wire-mesh bottom cages.
- Diet: Free access to Purina Rodent laboratory Chow #5001
- Water: Free access to water
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
No data. - Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw.
DOSAGE PREPARATION: Based on a specific gravity of 0.9754, appropriate amounts of the test substance were admixed with corn oil to achieve the required dose levels. Dosing solutions were agitated prior to administration.
CLASS METHOD
- Rationale for the selection of the starting dose: A preliminary range-finding study was performed to select dose levels for the LD50 phase of the experiment. The test substance was diluted in corn oil and administered to five groups of two male and two female rats, each, at levels of 5000, 1600, 500, 160 and 50 mg/kg bw. All animals were observed daily for three days of mortality. All rats surviving on Day 4 were sacrificed and discarded. - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: The animals were observed for signs of toxicity and mortality at 1, 3, 6 and 24 hours after dosing and daily thereafter for 14 days.
- Body weights: Individual body weights were recorded prior to dosing and at the time of sacrifice on Day 14.
- Necropsy of survivors performed: yes, all animals on Day 14 were sacrificed using CO2 exposure. Necropsies were performed on all animals at the time of sacrifice. - Statistics:
- Not performed.
- Preliminary study:
- No deaths occurred in any treatment groups. No signs of test substance induced toxicity were observed in animals administered 500 or 5000 mg/kg bw. Singular incidences of soft feces were observed in females receiving 50 and 160 mg/kg bw, and this finding was noted in one male receiving 1600 mg/kg bw at four and six hours after dosing.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: No signs of test substance induced toxicity were observed in any of the animals.
- Gross pathology:
- Sacrifice and gross examination of the animals on Day 14 revealed only mottled lungs which are considered to be an artifact of exposure to CO2. No gross tissue alterations attributable to treatment with the substance were observed in any of the animals.
- Interpretation of results:
- other: Not acute harmful.
- Remarks:
- According to Regulation (EC) No. 1272/2008.
- Conclusions:
- The acute oral toxicity test with the substance showed an LD50 of >5000 mg/kg bw. Based on this result the substance is not acute harmful.
- Executive summary:
In this study performed equivalent to OECD TG 401 guideline and performed in a GLP facility, 20 rats (10 males and 10 females) were administered with the substance at a dose level of 5000 mg/kg bw. None of the animals died. No abnormal clinical signs were observed. Gross pathological examinations at 14 days p.a. (terminal necropsy) revealed no test article dependent findings. Based on the results in this study, the substance is not acute harmful and the acute oral LD50 for the substance in male and female rats was determined to be >5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The acute oral toxicity result is of sufficient quality and adequate for this dossier.
Additional information
Acute oral:
In this study performed equivalent to OECD TG 401 guideline and performed in a GLP facility, 20 rats (10 males and 10 females) were administered with the substance at a dose level of 5000 mg/kg bw. None of the animals died. No abnormal clinical signs were observed. Gross pathological examinations at 14 days p.a. (terminal necropsy) revealed no test article dependent findings. Based on the results in this study, the substance is not acute harmful and the acute oral LD50 for the substance in male and female rats was determined to be >5000 mg/kg bw.
Justification for classification or non-classification
Based on the results in this study, the substance does not have to be classified for acute toxicity by the oral route according to Regulation (EC) No. 1272/2008 and its updates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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