Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate]

Endpoint summary

Description of key information

Short-term toxicity to fish

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 114.09 mg/l for Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] in 96 hrs. Based on the LC50 value, it can be concluded that the substance Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] can be considered as not toxic to aquatic environment and thus “not classified” as per the CLP criteria.

Short-term toxicity to aquatic invertebrates

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the short term toxicity on aquatic invertebrate predicted for Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041 -67-8). Effect concentration i.e EC50 value estimated to be 162.95 mg/l for Daphnia magna for 48 hrs duration. It can be concluded that the Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041-67-8 likely to be not toxic to aquatic invertebrates, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.

Toxicity to aquatic algae and cyanobacteria

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on algae was predicted for Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041-67-8). Effect concentration i.e EC50 value was estimated to be 528.64 mg/l for Pseudokirchneriella subcapitata for 72 hrs duration. It was concluded that the Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041-67-8) was likely to be not toxic to aquatic algae, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.

Additional information

Short-term toxicity to fish

The available predicted Study from validated tools for toxicity to fish endpoint of test chemical Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041-67-8) were summarised as follows:

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 114.09 mg/l for Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] in 96 hrs. Based on the LC50 value, it can be concluded that the substance Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] can be considered as not toxic to aquatic environment and thus “not classified” as per the CLP criteria.

Short-term toxicity to aquatic invertebrates

Three studies including predicted data from validated tools and experimental datafor toxicity to aquatic invertebrate endpoint of test chemical Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041-67-8) with relevant read across which is close to target using log Kow as primary descriptor were summarised as follows:

 

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the short term toxicity on aquatic invertebrate predicted for Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041 -67-8). Effect concentration i.e EC50 value estimated to be 162.95 mg/l for Daphnia magna for 48 hrs duration. It can be concluded that the Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041-67-8 likely to be not toxic to aquatic invertebrates, hence it can be considered to be“not classified”as per the CLP classification criteria for aquatic environment.

 

The above predicted results for target assisted by experimental data of read across chemicalPyridazine-3,6-diol (CAS: 123-33-1) from U.S. Environmental Protection Agency, 1992.Effective concentration to 50% of Daphnia magnafor48 Hour(s) is 107.500mg/L considering the mobility effect, the concentration is measured. It can be concluded that the Pyridazine-3,6-diol is not toxic to the aquatic environment

Another experimental data of read across chemicalTitanium dioxide (CAS: 13463-67-7 )frompeer reviewed journal,Journal of Nanoparticle Research 2009,The Lethal concentration to 50% of Daphnia magna for 48 hr is 143.387 mg/L. It can be concluded that the Titanium dioxide is not toxic to the aquatic environment.

 

Thus based on the effect concentrations which is in the range 120 mg/L to162.95 mg/lgive the conclusion that test substanceDialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041-67-8)was likely to be non-toxic to aquatic inverbrate at environmentally relevant concentrations and can be considered to be “not classified” as per the CLP classification criteria.

Toxicity to aquatic algae and cyanobacteria

Three studies including predicted data from validated tools and experimental datafor toxicity to aquatic algae endpoint of test chemical Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041-67-8) with relevant read across which is close to target using log Kow as primary descriptor were summarised as follows:

 

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on algae was predicted for Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041-67-8). Effect concentration i.e EC50 value was estimated to be 528.64 mg/l for Pseudokirchneriella subcapitata for 72 hrs duration. It was concluded that the Dialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041-67-8) was likely to be not toxic to aquatic algae, hence it can be considered to be“not classified”as per the CLP classification criteria for aquatic environment.

The above predicted results for target assisted by experimental data of read across chemicalTitanium dioxide(CAS: 13463-67-7)frompeer reviewed journalToxicology 2010The Effective concentration to 50% of Pseudokirchneriella subcapitata at 72hr is 241 mg/L. It can be concluded that the Titanium dioxide is not toxic to aquatic environment.

 

Another experimental data of read across chemicalCerium dioxide (CAS: 1306-38-3)frompeer reviewed journalEnvironmental Chemistry 2010,The Inhibition concentration to 50% of Pseudokirchneriella subcapitata in algal growth rate after 72hr is > 100 mg/L. It can be concluded that the Cerium dioxide is not toxic o the aquatic environment.

 

Thus based on the effect concentrations which is in the range > 100 mg/L to 528.64 mg/l give the conclusion that test substanceDialuminium tris[4-hydroxy-3-[(4-sulphonato-1-naphthyl)azo]naphthalenesulphonate] (Cas no. 84041-67-8)was likely to be non-toxic to aquatic algae at environmentally relevant concentrations and can be considered to be “not classified” as per the CLP classification criteria.