Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-045-8 | CAS number: 16969-10-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No experimental toxicokinetic study is available on 2-Hydroxy-3-phenoxypropyl acrylate. However, as per REACH guidance document R7.C (2014), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.
Based on the toxicological data and the physicochemical properties, an absorption of 2-Hydroxy-3-phenoxypropyl acrylate is expected after oral, dermal route or inhalation exposures.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
No experimental toxicokinetic study is available on 2-Hydroxy-3-phenoxypropyl acrylate. However, as per REACH guidance document R7.C (2014), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, including:
-Mean molecular weight: 222.24 g/mol
-Water solubility: 5.3 g/L (20°C) (soluble)
-Partition coefficient Log Kow: 2.02
-Vapour pressure: 0,00359 Pa
ABSORPTION
The high value of water solubility and the moderate value of the Log Kow of 2-Hydroxy-3-phenoxypropyl acrylate are favorable for an oral and dermal absorption. However, no clinical effects or mortality were observed after one single administration (2000 mg/kg) of 2-Hydroxy-3-phenoxypropyl acrylate by gavage (oral route) in rats. An oral absorption is expected to be moderate for 2-Hydroxy-3-phenoxypropyl acrylate. For the risk assessment, 100% of oral absorption is taken into account.
The low molecular mass (smaller than 500 g/mol) is favourable to a dermal absorption. Indeed, the dermal absorption of 2-Hydroxy-3-phenoxypropyl acrylate is possible. Moreover, a dermal absorption of 2-Hydroxy-3-phenoxypropyl acrylate is proven with the skin sensitisation study showing positive results in guinea-pigs. According to the IH skin perm (QSAR), the dermal absorption of 2-hydroxy-3-phenoxypropyl acrylate is 0.3 %. For the risk assessment, 10% of dermal absorption is taken into account.
Based on the low value of the vapour pressure (<0.01 Pa), 2-Hydroxy-3-phenoxypropyl acrylate is not considered as a volatile substance. However, based on the water solubility and log kow values, an absorption by inhalation is possible for 2-Hydroxy-3-phenoxypropyl acrylate. For the risk assessment, 100% of inhalation absorption is taken into account.
DISTRIBUTION and METABOLISM
No specific data is available on the distribution or metabolism of 2-Hydroxy-3-phenoxypropyl acrylate. No organ toxicity was showed in the acute and repeated studies.
ELIMINATION
Due to the high water solubility and the low molecular mass, the excretion of 2-Hydroxy-3-phenoxypropyl acrylate in the urines is expected to be high.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
