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EC number: 944-710-7
CAS number: -
The aim of the study was to assess the toxicity and to determine, if
possible, a no-effect level for the test substance following daily oral
(gavage) administration to rats for 4 consecutive weeks.
The study was conducted according to the following design:
Three groups of 5 male and 5 female Wistar rats were formed. Two doses
were tested: 150 and 1000 mglkg. The high dosage was selected on the
basis of a preliminary 7 day oral toxicity study. The animals received
the test substance daily by oral route (gavage).
A control group received the vehicle only, under the same conditions as
the treated animals.
The animals were observed for 4 weeks, during which mortality, body
weight, food consumption, clinical signs, clinical pathology and
pathology were recorded.
No mortality was observed in the study. No dose related body weight
decrease was observed in all treated groups throughout the treatment
period. No significant food consumption difference with the control
group was observed in treated groups. No abnormal clinical sign related
to treatment, no clinical biochemistry, no blood parameter change and no
significant morphological change was observed in all groups.
The no effect level was determined at 1000 mg/kg/day. The test substance
appears as a non toxic substance after a 28 day oral toxicity study in
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