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EC number: 944-710-7
CAS number: -
Rats of the CFY strain, in the weight range 140 to 186 g were starved
overnight before treatment with the test item.
The test item was prepared as a 20% suspension in aqueous gum tragacanth
(0.5%) and administered by oral intubation at a dosage volume of 25
Rats treated with the vehicle alone (25 ml/kg) served as controls.
During the observation period of 14 days, a record was kept of all signs
of toxicity. All rats were sacrificed terminally and examined
macroscopically in an attempt to identify any target organs.
Ten rats (five male and five female) were treated with the test item at
a dosage level of 5000 mg/kg bodyweight .
There were no mortalities.
Signs of reaction to treatment, observed shortly after dosing, consisted
of lethargy, piloerection, diuresis, diarrhoea and a slight increase in
salivation. Blue stained urine and faeces were observed from all rats.
Recovery of all animals, as judged by external appearance and behaviour,
was apparently complete within four days of treatment.
Bodyweight gains of all rats were within normal limits and terminal
autopsy findings were normal.
The acute median lethal oral dose (LD50) to rats of the test item was
found to be: greater than 5000 mg/kg bodyweight.
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