Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 271-282-2 | CAS number: 68527-77-5
Slight edema was present and erythema was observed during induction at 48 hours post dose 3 with test material. In positive control animals erythema was observed during induction at 24 hours post dose 9 and 48 hours post dose 3, 4, and 8. No irritation was observed in the negative control animals during induction or challenge periods.
One control animal was found dead on day 29.
The skin sentisation potential of the substance was investigated by performing a Buehler test similar to OECD 406 (1981) and according to GLP principles. Ten animals were used in the treatment group and 5 in the negative control group (instead of 20 resp. 10 animals according the guideline). A concentration of 60% was used for the inductions (total of 9) and the challenge. After the inductions, patchy erythema was observed among the animals. After the challenge with the substance 8 of the 10 and 7 of 10 animals showed slight or confluent or moderate patchy erythema (score 1) at the naive site at 24 and 48 hours, respectively. At the induction site slightly more effects were observed. Reliable negative (no response during challenge) and positive controls were included. Based on the positive results, the substance is considered to be a sensitiser under the conditions of the test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again