Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source, compilation of data on toxicokinetics and metabolism of very long chain fatty esters, acids and alcohols
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Nutritional significance and metabolism of very long chain fatty alcohols and acids from dietary waxes.
Author:
Hargrove, J. L., Greenspan, P., Hartle, D. K.
Year:
2004
Bibliographic source:
Experimental Biology and Medicine, 229: 215-226

Materials and methods

Type of study / information:
compilation of in vitro and in vivo data
Principles of method if other than guideline:
review article of aspects of toxicokinetics of very long chain fatty alcohols and acids from dietary waxes
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Inherited disorders of fatty alcohol and acid metabolism can produce various diseases, e.g.

Adrenoleukodystrophy (caused by accumulation of very long chain fatty acids in neuronal tissues)

Sjögren-Larsson syndrome (caused by accumulation of very long chain fatty alcohols in tissues)

others are: Zellweger syndrome, infantile Refsum's disease

Applicant's summary and conclusion

Conclusions:
Inherited disorders of fatty alcohol and acid metabolism can produce various diseases
Executive summary:

Inherited disorders of fatty alcohol and acid metabolism can produce various diseases, e.g.

Adrenoleukodystrophy (caused by accumulation of very long chain fatty acids in neuronal tissues)

Sjögren-Larsson syndrome (caused by accumulation of very long chain fatty alcohols in tissues),

other are: Zellweger syndrome and infantile Refsum's disease.