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EC number: 216-374-5
CAS number: 1569-02-4
The available aquatic toxicology data for ethoxypropanol are summarized
below. The available direct and indirect evidence consistently indicate
that ethoxypropanol is of low acute toxicity to aquatic organisms and
that algae are the most sensitive trophic level. This trend is clearly
indicated by the predictions of a QSAR and is strongly supported by the
available evidence from measured data, which is principally available
from read across substances, although it should be noted that the
differences between toxicity to the threee trophic levels is actually
quite small and consistent with the mode of action being that of
non-polar narcosis. The structure is consistent with substances likely
to act by this mode (Verhaar, 1992). Non-polar narcosis is rapidly and
completely reversible and is correlated with lipophilicity rather than
any specific chemical property (Shultz, 1989). The data from algae are
taken forward as the critical end point from which to derive the PNEC. A
reliable algal toxicity study is available for ethoxypropanol but this
is only a limit study carried out for classification and labelling
purposes. It does not provide useful information for derivation of the
PNEC. Therefore data from a read across substance propoxypropanol
(propylene glycol propyl ether) is used. This is a conservative approach
as the latter would be predicted to be more toxic than the former.
Shultz TW (1989) “Non polar narcosis. A review of the mechanism of
action for baseline toxicity.” Aquatic Toxicology and Hazard Assessment,
12th vol, ASTM STP1027, ed Cowgill & Williams, p104-9.
Verhaar HJM et al (1992) “Classifying environmental pollutants. 1.
Structure-activity relationships for prediction of aquatic toxicity”.
Chemosphere 25, 4, 471-91.
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