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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02/04/2014 – 14/04/2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted in compliance with GLP and EU guideline, available as unpublished report, no restrictions, fully adequate for assessment.
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
yes (incl. certificate)
Remarks:
Chilworth Technology Limited, Beta House, Southampton Science Park, Southampton SO16 7NS, United Kingdom
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
2.4
pH:
>= 8.03 - <= 8.94
Remarks on result:
other: Temperature was kept constant (+/-1°C) between 20-25°C
Details on results:
- Preliminary estimation: log Pow = 1.301. Test material is relatively non-polar. Such materials have a tendency of forming of microemulsion when dissolved in polar solvents. The test was performed visually hence effect of micro-emulsion must be considered in interpreting the estimated Log Pow.
- Formal Partition Coefficient Analysis: mean log Pow = 2.403. A whitish layer was observed at the octanol/water interface in every flask. The reason for the white layer could not be determined. Possible sample loss at the octanol-water interface must be considered when interpreting the test result.
Conclusions:
The partition coefficient of the test substance between n-octanol and aqueous phase is 2.4 (log Pow).
Executive summary:

In a study performed according to EU Method A8 and GLP, the partition coefficient of the test substance between n-octanol and aqueous phase was determined using the shake-flask method. The partition coefficient of the test substance between n-octanol and aqueous phase was determined to be 2.4 (log Pow).

Description of key information

In a study performed according to EU Method A8 and GLP, the partition coefficient of the test substance between n-octanol and aqueous phase was determined using the shake-flask method. The partition coefficient of the test substance between n-octanol and aqueous phase was determined to be 2.4 (log Pow). 

Key value for chemical safety assessment

Log Kow (Log Pow):
2.4

Additional information