Phenethyl propionate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal.

Data source

Reference

Reference Type:

publication

Title:

Acute Toxicity Studies with Insect Attractants

Author:

Morton Beroza, M. N. Inscoe, P. H. Schwartz, Jr., M. L. Keplinger, and C. W. Mastri

Year:

1975

Bibliographic source:

Toxicology and Applied Pharmacology 31,421-429

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

The primary skin irritation test for 2-phenylethyl propanoate (CAS No: 122-70-3) was conducted on six New Zealand albino rabbits to assess its adverse effects on skin.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Phenethyl propionate

EC Number:

204-567-7

EC Name:

Phenethyl propionate

Cas Number:

122-70-3

Molecular formula:

C11H14O2

IUPAC Name:

2-phenylethyl propanoate

Test material form:

liquid

Details on test material:

- Name of test material : 2-phenylethyl propanoate
- Molecular formula: C11H14O2
- Molecular weight: 178.2296 g/mol
- Smiles notation: c1(CCOC(=O)CC)ccccc1
- InChl: 1S/C11H14O2/c1-2-11(12)13-9-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3
- Substance type: Organic
- Physical state: Liquid

Specific details on test material used for the study:

- Name of test material (IUPAC name): 2-phenylethyl propanoate
- Common name: Phenethyl propionate (PEP)
- Molecular formula: C11H14O2
- Molecular weight: 178.2296 g/mol
- Smiles notation: c1(CCOC(=O)CC)ccccc1
- InChl: 1S/C11H14O2/c1-2-11(12)13-9-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:

rabbit

Strain:

other: New Zealand albino

Details on test animals or test system and environmental conditions:

Weight at study initiation: 1.9-3.1 kg

Test system

Type of coverage:

occlusive

Preparation of test site:

clipped

Remarks:

intact and abraded

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

concentration applied :70%
Amount :0.5 ml per dose

Duration of treatment / exposure:

24 hours

Observation period:

24/72 hours

Number of animals:

6 rabbits (Male and Female)

Details on study design:

TEST SITE
Area of exposure: back and flanks
% coverage: Not reported
Type of wrap if used: 2-in.-square gauze patches that were secured with masking tape, and the trunk of each animal was wrapped with plastic sheeting to maintain the patches in position
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 and 72 hours

SCORING SYSTEM: Draize scoring system; maximum score is 8.0

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 24and 72 hours

Score:

1.2

Max. score:

8

Reversibility:

not specified

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

No skin irritation was observed in treated animals.

Applicant's summary and conclusion

Interpretation of results:

other: Not irritating

Conclusions:

The test material 2-phenylethyl propanoate (CAS No: 122-70-3) was evaluated for primary skin irritation in six New Zealand albino rabbits. It was observed to have a Mean Primary Irritation Score of 1.2. Thus according to FIFRA categories for skin irritation, 2-phenylethyl propanoate (CAS No: 122-70-3) was considered to be not irritating (Primary Irritation Score <5).

Executive summary:

The primary skin irritation test for chemical 2-phenylethyl propanoate (CAS No: 122-70-3) was conducted on six New Zealand albino rabbits to assess its adverse effects on skin.

 

 During the test,the hairs were clipped from the back and flanks of rabbits, and two sites located lateral to the midline of the back and approximately 10 cm apart were selected for the test; one site was abraded by making four epidermal incisions, two perpendicular to the other were selected for the test; one site was abraded by making four epidermal incisions, were selected for the test; one site was abraded by making four epidermal incisions, two perpendicular to the other two.

 

A 0.5-ml dose of 70%2-phenylethyl propanoatewas applied to each site. The sites were immediately covered with 2-in.-square gauze patches that were secured with masking tape, and the trunk of each animal was wrapped with plastic sheeting to maintain the patches in position and retard evaporation of the test material.

 

 After 24 hr the plastic wrappings and gauze patches were removed, and the intact and abraded skin sites were scored separately for erythema and edema on a graded scale of 0 to 4 according to Draize scoring system after 72 hr, the sites were scored again. The mean primary irritation score (maximum = 8) represents an average of the 24- and 72-hr ratings of the intact and abraded sites.

 

For skin irritation, the category for to be not an irritant was, if no irritation was observed or the primary irritation score was <5according to FIFRA.

 

The 2-phenylethyl propanoatewas observed to have a Mean Primary Irritation Score of 1.2. Thusaccording to FIFRA categories for skin irritation,2-phenylethyl propanoate (CAS No: 122-70-3) was considered to be not irritating (Primary Irritation Score <5).