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EC number: 500-005-2 | CAS number: 9003-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study in Rat for test chemical
- Author:
- U.S .National library of medicine
- Year:
- 2 017
- Bibliographic source:
- ChemID plus A TOXNET DATABASE.2017
- Reference Type:
- secondary source
- Title:
- Acute biological studies on range oftest chemical
- Author:
- NTRL
- Year:
- 1 992
- Bibliographic source:
- National Technical Information Service
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of test chemical was performed in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Formaldehyde, oligomeric reaction products with phenol
- EC Number:
- 500-005-2
- EC Name:
- Formaldehyde, oligomeric reaction products with phenol
- Cas Number:
- 9003-35-4
- Molecular formula:
- (C6H6O.CH2O)x
- IUPAC Name:
- Formaldehyde, oligomeric reaction products with phenol
- Details on test material:
- - Name of test material (as cited in study report): Phenol-formaldehyde resin
- Molecular formula: C6H6O.CH2O)x-
- Molecular weight: 34.133 g/mol
- Substance type: organic
- Physical state: solid
- Smiles notation: c1(c(c(ccc1)[CH])O)O[CH]
- InChl: 1S/C8H6O2/c1-6-4-3-5-7(10-2)8(6)9/h1-5,9H
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data available
- Doses:
- As mentioned in table below
- No. of animals per sex per dose:
- Total :10
male:5
female:5 - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily
- Necropsy of survivors performed: No data available
- Other examinations performed: clinical signs and postmortem examination
Were performed - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- Acute oral studies indicate that LD50 values of test chemical in the rat are proportional to their free test substance content.
Any other information on results incl. tables
SR.NO |
Resin type |
Clinical signs |
|
1 |
Phenol Formaldehyde Novolak Ground With Hexamine (6%) |
Tremors and convulsion in animal subsequent prostration with twitching and staining around the mouth & chin. |
|
2 |
Phenol Formaldehyde Novolak Ground With Hexamine (9.1%) |
Nothing abnormal detected. |
|
3 |
Ground Phenol Formaldehyde Novolak Without Hexamine |
Nothing abnormal detected. |
|
4 |
Cashew Modified Phenol Formaldehyde Novolak Ground With Hexamine (7. 9%) |
Slight Tremors in 4 animals. Salivation and resultant fur staining with evidence of gastro-intestinal disturbance. |
|
5 |
Spray Dried Phenol Formaldehyde Resol |
Seadation, Ruffled fur and arched posture. |
|
6 |
Resorcinol Phenol Formaldehyde Novolak In Ethanol (7. 5%) |
Seadation and convulsion with Ruffled fur and arched posture. |
|
7 |
Phenol Formaldehyde Resol In Ethanol (43%) |
Nothing abnormal detected. |
|
8 |
Phenol Formaldehyde Resol In Ethanol (19. 7%) |
Seadation and convulsion with Ruffled fur and arched posture. |
|
9 |
Phenol Formaldehyde Resol In Ethanol (30%) |
Transient salivation and transient staining. |
|
10 |
Water Dilutable Phenol Formaldehyde Liquid Resol |
Transient salivation (with associated staining) and body Tremors at all dose level. Some staining in urogenital region. |
|
11 |
Phenol Formaldehyde Liquid Resol |
Seadation, Ruffled fur, arched posture. Some convulsion at highest dose level |
|
12 |
Phenol Formaldehyde Liquid Resol |
Transient salivation and associated staining slight body tumor in one animal. |
|
13 |
Phenol Formaldehyde Liquid Resol |
Tumors and convulsion with prostration and twitching at both dose level. Salivation was seen in almost all animals. No treatment related microscopic change at autopsy in all surviving animals |
|
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The LD50 value was considered to be >5000 mg/kg,when male and female rats were treated with test chemical orally.
- Executive summary:
Acute oral toxicity test was carried out for different grades of test chemical. Groups of five male and five female rats were given single oral doses of the test materials. The animals were observed at frequent intervals for the first day and then at least daily over a 14-day observation period. All the animals dying during this period and the surviving animals, which were killed on day 14, were subjected to a post mortem examination to note any microscopic abnormalities.Administration of different grades of test chemical in male and female rat resulted in no or minimum, sign of toxicity at doses up to 5000 mg/kg. Hence,The LD50 value was considered to be >5000 mg/kg,when male and female rats were treated with test chemical orally.
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