Registration Dossier
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EC number: 202-336-5 | CAS number: 94-47-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from computational model developed by USEPA
- Qualifier:
- according to
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- Long term toxicity to aquatic invertebrate daphnia was carried out according to the EPISUITE.
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Common name: Water flea
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 21 d
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.316 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of no effects observed in a static freshwater system, the NOEC value for the substance is estimated to be 0.316 mg/l for daphnia for 21 days of exposure duration.
- Executive summary:
Based on the prediction done using ECOSAR class, the long term toxicity on aquatic invertebrate daphnia was predicted for test substance. On the basis of no effects observed in a static freshwater system, the NOEC value for the substance is estimated to be 0.316 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to aquatic invertebrate daphnia at environmentally relevant concentrations and can be considered to be classified in aquatic chronic 2 category as per the CLP classification criteria.
Reference
Description of key information
Based on the prediction done using ECOSAR class, the long term toxicity on aquatic invertebrate daphnia was predicted for test substance. On the basis of no effects observed in a static freshwater system, the NOEC value for the substance is estimated to be 0.316 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to aquatic invertebrate daphnia at environmentally relevant concentrations and can be considered to be classified in aquatic chronic 2 category as per the CLP classification criteria.
Key value for chemical safety assessment
- EC10, LC10 or NOEC for freshwater invertebrates:
- 0.316 mg/L
Additional information
Based on the various long term studies available for the test chemical, studies were reviewed to determine the toxic nature of test chemical on the mobility and reproduction of aquatic invertebrates. The studies are as mentioned below:
Based on the prediction done using ECOSAR class, the long term toxicity on aquatic invertebrate daphnia was predicted for test substance. On the basis of no effects observed in a static freshwater system, the NOEC value for the substance is estimated to be 0.316 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to aquatic invertebrate daphnia at environmentally relevant concentrations and can be considered to be classified in aquatic chronic 2 category as per the CLP classification criteria.
Above study was supported by the second study. 21 days long term toxicity tests of test chemical were performed on daphnia magna. After the exposure of test chemical with daphnia magna for 21 days, no effects were observed on the reproduction rate of daphnia magna. Thus the NOEC was observed at 0.84 mg/l. Based on the NOEC value, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.
Similar aim of this study was to access the effect of test chemical on the reproduction and growth rate of aquatic invertebrate daphnia magna. Test conducted for 10 days. Based on the low effect of test chemical on the growth and reproduction of daphnia magna after the exposure of 10 days, LOEC was observed at 0.1 mg/l. Based on the LOEC, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.
In the fourth study long term toxicity test was performed on Daphnia magna for 21 days according to the OECD guideline 211. 20 ml test tubes were used as a vessel with different concentrations in which 1 larva at each test tubes were kept for experiment. After 48 hrs test water were replaced and count the cumulative numbers of broods. Based on that both Immobilized bodies and cumulative numbers of broods NOEC was determined. On the basis of above experiment the NOEC value for test chemical to Daphnia magna was found to be 0.84 mg/l concentration.
Thus based on the above effects and studies available on the long term effect on aquatic invertebrate, test chemical consider to be toxic to the aquatic invertebrates and hence classified in aquatic chronic 2 category as per the CLP classification criteria.
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