Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 204-627-2 | CAS number: 123-43-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data from secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Skin sensitization test of Methanesulfonic acid was performed by Buehler Test in guinea pig
- Author:
- US EPA
- Year:
- 2 016
- Bibliographic source:
- High Production Volume Information System (HPVIS), 2016
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Skin sensitization study of Methanesulfonic acid was performed by Buehler test in guinea pig.
- GLP compliance:
- not specified
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- Methanesulphonic acid
- EC Number:
- 200-898-6
- EC Name:
- Methanesulphonic acid
- Cas Number:
- 75-75-2
- Molecular formula:
- CH4O3S
- IUPAC Name:
- methanesulfonic acid
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): Methanesulfonic acid
- Molecular formula: CH4O3S
- Molecular weight: 96.10g/mole
- Substance type: Organic
- Physical state: : No data available
- Purity: No data available
- Impurities (identity and concentrations): No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Methanesulfonic acid
- Molecular formula: CH4O3S
- Molecular weight: 96.10g/mole
- Substance type: Organic
- Physical state: : No data available
- Purity: No data available
- Impurities (identity and concentrations): No data available
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: Harlan Sprague Dawley (P.O.
Box 29176, Indianapolis, Indiana
46229)
- Age at study initiation: No data available
- Weight at study initiation: 429.6 ± 18.8(males), 400.5 ± 27.6g (females)
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, open
- Vehicle:
- water
- Concentration / amount:
- 0.3 ml of 50 % occlusive epicutaneous
- Day(s)/duration:
- 14 days
Challenge
- No.:
- #1
- Route:
- epicutaneous, open
- Vehicle:
- water
- Concentration / amount:
- 0.3 ml of 25 % occlusive epicutaneous
- Day(s)/duration:
- 24h
- No. of animals per dose:
- Total :30
Test group :10 male ,10 female
Control group :5 male ,5 female - Details on study design:
- Details on study design
RANGE FINDING TESTS:
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: three ,on day 1st ,7th and 14th
- Exposure period:6 hr
- Test groups:20
- Control group:10
- Site: left shoulder
- Frequency of applications: after 7 days
- Duration: 14 days
- Concentrations: 0.3 ml of 50 % occlusive epicutaneous
B. CHALLENGE EXPOSURE
- No. of exposures: one
- Day(s) of challenge:14 days
- Exposure period:24hr
- Test groups:20
- Control group:10
- Site: right flank
- Concentrations: 0.3 ml of 25 % occlusive epicutaneous
- Evaluation (hr after challenge):24hr
OTHER: Freunds Complete Adjuvant (FCA) not used - Challenge controls:
- No data available
- Positive control substance(s):
- not required
Study design: in vivo (LLNA)
- Statistics:
- No data available
Results and discussion
- Positive control results:
- No data available
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.3 ml of 25 % occlusive epicutaneous
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- No indication of skin sensitization
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: Not sensitizing
- Remarks:
- No skin sensitization reaction noted
- Conclusions:
- The Methanesulfonic acid (75-75-2) was considered to be not sensitizing to guinea pig.
- Executive summary:
The skin sensitizing study of Methanesulfonic acid was carried out in Hartley guinea pig in group of 20 by Buehler test method.. Vehicle control group 5 animals /sex also observed .Pilot study done before start of experiment. Test material dissolved in water .Topical induction was by application of test substance 0.3 ml of 50 % occlusive epicutaneous for 6 hours on left shoulder for 3 times in 14 days on 1stday ,7thdays and on 14thdays An interval of 14 days animals challenged by 0.3 ml of 25 % occlusive epicutaneouspatch for 24 hours. Cutaneous reactions were evaluated at 24 hours.After challenge no skin reactions were observed. Therefore, based on the results obtained, the Methanesulfonic acid (75 -75 -2) was considered to be non-sensitizing to skin of guinea pig.
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