Registration Dossier

Administrative data

Description of key information

Acute inhalation whole body exposure LC50 was greater than 5400 mg/m3 (DCC, 2001).

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LC50
Value:
5 400 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

In an acute inhalation whole-body exposure study of trimethylsilane (DCC, 2001) there were no mortalities or remarkable findings. The 4-hour LC50 value was found to be greater than 5400 mg/m3 (5.4 mg/L, 1774 ppm) which was the highest concentration tested.


Justification for classification or non-classification

Based on the available information trimethylsilane does not require classification for acute toxicity according to Regulation (EC) No 1272/2008.