Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
genetic toxicity in vitro, other
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
PERCEPTA software results

Data source

Reference
Reference Type:
other: QSAR analisys
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
no guideline followed
Version / remarks:
QSAR analisys
Principles of method if other than guideline:
ACDlabs PERCEPTA software result for genotoxicity of the substance (Propability of positive Ames test)
GLP compliance:
not specified
Type of assay:
other: QSAR

Test material

Constituent 1
Chemical structure
Reference substance name:
4-[(oxiran-2-yl)methoxy]-9H-carbazole
EC Number:
610-764-2
Cas Number:
51997-51-4
Molecular formula:
C15H13NO2
IUPAC Name:
4-[(oxiran-2-yl)methoxy]-9H-carbazole

Results and discussion

Test results
Key result
Species / strain:
other: QSAR
Remarks on result:
mutagenic potential (based on QSAR/QSPR prediction)

Applicant's summary and conclusion

Conclusions:
The substance is possible mutagene according to QSAR analyis. Recommended classification is Mutagen Cathegory 2, H341 Suspected of causing genetic defects.