Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 809-852-5 | CAS number: 3395-98-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There are no specific studies available regarding toxicokinetics, metabolism and distribution. Absoption by the oral, dermal and inhalation routes is expected. Moreover, distribution through extracellular body fluids is likely. The formation of reactive metabolites is unlikely. Excretion will most likely occur via the urine. No bioaccumulation is expected.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
In line with chapter R.7 c (ECHA, 2014) the main toxicokinetic properties of 5 -methyl-3 -vinyl-1,3 -oxazolidin-2 -one are assessed on the basis of its physico-chemical properties and with special regard to the results of the standard toxicity studies performed with this substance. Specific toxicokinetics or dermal absorption studies are not available for 5 -methyl-3 -vinyl-1,3 -oxazolidin-2 -one.
1. Relevant physico-chemical properties of 5 -methyl-3 -vinyl-1,3 -oxazolidin-2 -one
Molecular weight: 127.14 g/mol
logPow: 0.8 (at 20°C)
Water solubility: 90.9 g/L (at 20 °C, pH 9.5)
Vapour pressure: 0.022 hPa (at 20 °C)
Boiling point: 254 °C (at 1013.25 hPa)
Surface tension: Based on chemical structure, no surface activity is predicted.
Particle size: Substance is marketed or used in a non solid or granular form.
2. Absorption:
Based on its low molecular weight, moderate logPow and relatively high water solubility 5 -methyl-3 -vinyl-1,3 -oxazolidin-2 -one is likely to be absorbed in the GI tract. The moderate logPow value of 0.8 (at 23°C, pH 9.5) indicates that the substance is lipophilic,i. e.in the range between -1 and 4, and will thus diffuse well across plasma membranes. In addition, gastro-intestinal absorption is considered to be triggered by passage through aqueous membrane pores or carriage with the bulk passage of water, which is favoured for small (molecular weight < 200 g/mol), water soluble substances. It is unclear whether an active transport exists.
Overall, quantitative gastrointestinal absorption is expected for 5 -methyl-3 -vinyl-1,3 -oxazolidin-2 -one, based on its physicochemical properties.
With a logPow value between -1 and 4 and in view of the above considerations for the oral route of exposure, 5 -methyl-3 -vinyl-1,3 -oxazolidin-2 -one is considered to be absorbed directly across the respiratory tract epithelium by passive diffusion when its vapour or particles reach the alveolar regions of the lungs. However, based on the low volatility and the high boiling point, generally only low amounts of the substance will be available for inhalation under ambient conditions.
With respect to the physicochemical properties (molecular weight, logPow and water solubility), it is concluded that dermal absorption is possible.
This assessment is substantiated by signs of systemic toxicity noted in acute and repeated dose toxicity studies.
3. Distribution/Metabolism:
Distribution of 5 -methyl-3 -vinyl-1,3 -oxazolidin-2 -one could be assumed based on the available toxicity studies. The logPow >0 and the good water solubility support this conclusion.
Generally, metabolism will render a xenobiotic molecule more polar and harmless, leading to fast and quantitative excretion. For 5 -methyl-3 -vinyl-1,3 -oxazolidin-2 -one, no conversion into a metabolite that was more cytotoxic or more genotoxic than the parent substance was noted when comparing in vitro test results with metabolic activation to in vitro test results without metobolic activation system (genetic toxicity tests). Based on this, a clear indication is given that the formation of reactive metabolites is unlikely.
4. Excretion:
The low molecular weight (below 300 g/mol in the rat) and good water solubility of 5 -methyl-3 -vinyl-1,3 -oxazolidin-2 -one lead to the conclusion that urinary excretion will be the most relevant route of excretion. This is considered to apply also to the potential polar metabolites. The log Pow indicates no potential for accumulation in the tissues.
Reference
- ECHA (2014). Guidance on information requirements and chemical safety assessment, chapter R.7c: Endpoint specific guidance. ECHA-14 -G-06-EN. R.7.12 Guidance on Toxicokinetics.
- EFSA (2012). Guidance on dermal absorption. EFSA Journal: 10 (4), 2665.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
