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Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
29 July 2015 to 22 October 2015
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Version / remarks:
13 April 2004
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Radiolabelling:
no
Analytical monitoring:
yes
Duration:
144 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
> 1.02 - < 1.03 g/L
Remarks:
<10% hydrolysis after 5 days
Duration:
144 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
> 0.989 - <= 0.989 g/L
Remarks:
<10% hydrolysis after 5 days
Duration:
144 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
> 1.01 - < 1.03 g/L
Remarks:
<10% hydrolysis after 5 days
Number of replicates:
Duplicates
Positive controls:
no
Negative controls:
no
Preliminary study:
For the preliminary test the sample solutions were maintined at 50.0 Deg C , pH 4, 7 and 8 for 144 h. The results indicated that it was not necessary to undertake further testing.
Test performance:
Linearity of the detector response with respect to concentration was assessed over the nominal concnetration range of 100 - 2000 mg/L, Correlation coefficients of >0.9994 were obtained.
Transformation products:
no
% Recovery:
> 98.8 - < 100
pH:
4
Temp.:
50 °C
Duration:
144 h
Remarks on result:
hydrolytically stable based on preliminary test
% Recovery:
> 98.8 - < 101
pH:
7
Temp.:
50 °C
Duration:
144 h
Remarks on result:
hydrolytically stable based on preliminary test
% Recovery:
> 97.1 - < 97.8
pH:
9
Temp.:
50 °C
Duration:
144 h
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
hydrolytically stable based on preliminary test
Validity criteria fulfilled:
yes
Remarks:
lnearity of the detector response over 100-2000 mg/L, Correlation coefficient >0.9994

Description of key information

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information