Registration Dossier

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1980
Report Date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified

Method

Species / strainopen allclose all
Species / strain:
S. typhimurium TA 98
Metabolic activation:
with
Species / strain:
E. coli WP2 uvr A
Metabolic activation:
not specified
Species / strain:
S. typhimurium TA 100
Metabolic activation:
without
Species / strain:
S. typhimurium TA 1535
Metabolic activation:
without
Species / strain:
S. typhimurium TA 1537
Metabolic activation:
with and without

Results and discussion

Test resultsopen allclose all
Species / strain:
S. typhimurium TA 98
Metabolic activation:
with
Genotoxicity:
negative
Cytotoxicity:
yes
Species / strain:
S. typhimurium TA 100
Metabolic activation:
without
Genotoxicity:
negative
Cytotoxicity:
yes
Species / strain:
S. typhimurium TA 1535
Metabolic activation:
without
Genotoxicity:
negative
Cytotoxicity:
yes
Species / strain:
S. typhimurium TA 1537
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity:
yes
Species / strain:
E. coli WP2 uvr A
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity:
no

Applicant's summary and conclusion

Conclusions:
The Tri (n-octyl) phosphine was not considered to be genotoxic in the Bacterial Reverse Mutation Assay.
Executive summary:

The Tri (n-octyl) phosphine was tested for mutagenicity in an Ames test.

TA-98, TA100, TA-1535, TA-1537 and E.Coli WP-2 uvrA were tested with or without metabolic activation in disc test and plate test.

No genotoxic effect were noted at the highest dosed tested.

The Tri (n-octyl) phosphine was not considered to be genotoxic in the Bacterial Reverse Mutation Assay.