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EC number: 225-234-2 | CAS number: 4731-53-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1985-03-11 to 1985-03-29
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trioctylphosphine
- EC Number:
- 225-234-2
- EC Name:
- Trioctylphosphine
- Cas Number:
- 4731-53-7
- Molecular formula:
- C24H51P
- IUPAC Name:
- trioctylphosphane
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adults (5 males and 1 female)
- Housing:Individually housed
- Cage: suspended, stainless steel
- Diet (e.g. ad libitum): Lab rabbit chow HF (Purine #5326)
- Water (e.g. ad libitum): Automatic watering system Municipal water supply (Elizabeth town water Co)
- Acclimation period: 15 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 15.6 °C - 21.1 °C (60 - 70 °F)
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12h / 12h
IN-LIFE DATES: From: To: 1985-03-26 to 1985-03-29
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: Clipped and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- Approximately 24h
- Observation period:
- 72h
- Number of animals:
- 6 (5 males and 1 female)
- Details on study design:
- TEST SITE
- Area of exposure: back (between scapular and lumbar region)
- % coverage: 2.54 cm² (1 x 1 inch)
- Type of wrap if used: Plastic sheeting was wrapped around the animal and secured with tape. Plastic sheeting was then wrapped around the animal and secured with tape to retard evaporation an keep the test substance in contact with the skin without undue pressure. Elizabethan collars were then placed on the animals to prevent disruption of the wrappings and ingestion of the test material.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The test sites were gently wiped free of excess test material with a paper towel and water.
- Time after start of exposure: 24h
OBSERVATION TIME POINTS
30 minutes after removal of wrappings and 72h after initiation of the treatment
SCORING SYSTEM:
- Method of calculation:
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24/72h
- Score:
- 6.3
- Max. score:
- 8
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3.7
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2.8
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2.1
- Max. score:
- 4
- Reversibility:
- not specified
Any other information on results incl. tables
Individual dermal irritation scores – 24h and 72h
Time |
Sites |
Type |
6443 M |
6444 F |
6469 M |
6453 M |
6445 M |
6451 M |
Mean score |
24h |
Right side (non-abraded) |
Erythema |
4S |
4S |
4S |
3 |
3 |
4S |
3.7 |
Edema |
3 |
3 |
3 |
2 |
3 |
3 |
2.8 |
||
Left side (Abraded) |
Erythema |
4S |
4S |
4S |
3 |
3 |
4S |
3.7 |
|
Edema |
3 |
4 |
3 |
2 |
2 |
3 |
2.8 |
||
72h |
Right side (non-abraded) |
Erythema |
4N |
4N |
4N |
4N |
4N |
4N |
4.0 |
Edema |
2 |
2 |
2 |
2 |
2 |
2 |
2.0 |
||
Left side (Abraded) |
Erythema |
4 |
4N |
4N |
4N |
4N |
4N |
4.0 |
|
Edema |
2 |
2 |
2 |
2 |
2 |
3 |
2.2 |
||
|
Total |
25.2 |
|||||||
|
PDII |
6.3 |
N : Necrosis
S : Superficial necrosis
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- The substance was corrosive to the skin. At 24h, four of six animals had superficial necrosis with moderate or severe edema at both the intact and abraded sites and two had mederate to severe erythema and edema. By 72h, all six animal had necrosis et the intact and/or abraded sites.
The primary Iirritation Index is 6.3 - Executive summary:
In an in vivo skin corrosion study on rabbits, 0.5 mL of trioctylphosphine was applied on intact or abraded skin of rabbit.
Observations at 24h and 72h after application showed edema, erythema and necrosis.
A PDII was calculated to be 6.3.
The substance was considered to be corrosive to the skin.
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