Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

The oral and dermal LD50 of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tris(C12 -13 branched-alkyl) esters and the similar substance were found to be > 2000 mg/kg bodyweight. Therefore the substance is practically nontoxic after short-term exposure. Therefore a DNEL after short-time exposure must not need derived.

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tris(C12 -13 -branched-alkyl) esters and the similar substances are neither an eye irritant nor a skin irritant, therefore also no local DNEL were derived.

There was no evidence of toxicity after oral gavage administration of 1000 mg/kg bw/d of the structural related tri(hexyl octyl decyl) citrate for 28 days. Based on the study the NOAEL was considered to be at least 1000 mg/kg bw/d. Therefore no hazard is expected and no DNEL has to be derived.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population

The oral and dermal LD50 of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tris(C12 -13 branched-alkyl) esters and the similar substance were found to be > 2000 mg/kg bodyweight. Therefore the substance is practically nontoxic after short-term exposure. Therefore a DNEL after short-time exposure must not need derived.

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tris(C12 -13 -branched-alkyl) esters and the similar substances are neither an eye irritant nor an skin irritant, therefore also no local DNEL were derived.

There was no evidence of toxicity after oral gavage administration of 1000 mg/kg bw/d of the structural related tri(hexyl octyl decyl) citrate for 28 days. Based on the study the NOAEL was considered to be at least 1000 mg/kg bw/d. Therefore no hazard is expected and no DNEL has to be derived.