1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tri-C12-13-branched alkyl esters

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

activated sludge respiration inhibition testing

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Please see Analogue Approach

Reason / purpose for cross-reference:

read-across source

Key result

Duration:

3 h

Dose descriptor:

EC50

Effect conc.:

> 1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

inhibition of total respiration

Remarks:

respiration rate

Description of key information

In comparison to the inoculum controls the respiration rate of the activated sludge was inhibited between 4.4 % and 20.1 % up to the highest tested concentration of nominal 1000 mg of the source substance Tri (hexyl, octyl, decyl) citrate /L. However, no concentration-effect relationship could be determined. Thus, the respiration rate was not significantly inhibited up to the highest tested concentration. Concentrations exceeding 1000 mg/L nominal were not tested.

From these inhibition rates, the 3-hour EC20 and EC50 could not be quantified. Nevertheless, the 3-hour EC50 was clearly higher than 1000 mg test substance/L under the present test conditions.

It is expected that the result is useful for the target substance 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tris(C12-13-branched-alkyl) ester.

Key value for chemical safety assessment

EC50 for microorganisms:

1 000 mg/L