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EC number: 944-989-5
CAS number: -
Log BCF (regression-based estimate): 0.50
(BCF = 3.16 L/kg wet-wt)
Biotransformation Half-Life (days) : 5.98
(normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): -0.05
(BAF = 0.893 L/kg wet-wt)
Log Kow used by BCF estimates: 16.32
Equation Used to Make BCF estimate: Log BCF
= -0.49 log Kow + 7.554 + Correction Correction(s): Value No Applicable
Correction Factors Minimum Log BCF of 0.50 applied when Log Kow > 7
Estimated Log BCF = 0.500 (BCF = 3.162 L/kg
The BCFBAF version 3.01 programme of the EPI
Suite software (v 4.10) was used to predict either a log BCF of 0.5 (BCF
of 3.16 L/kg) based on a regression estimate or a log BAF of - 0.05 (BAF
of 0.893 L/kg) based on the Arnot-Gobas upper trophic model both using
the smiles codes of tristridecyl 2
-hydroxypropane-1,2,3 -tricarboxylate and tridodecyl 2
-hydroxypropane-1,2,3 -tricarboxylate representing Cosmacol ECI .
Because the Arnot-Gobas upper trophic model takes also into account
metabolism of the substance by the organism it is lower. The QSAR-data
are supported by the results of the pharmacokinetics. Cosmacol ECI will
be hydrolysed, absorbed and efficiently metabolised into water soluble
metabolites, which is supported by the molecular structure of Cosmacol
ECI and its physico-chemical properties.
It is concluded that Cosmacol ECI will not
accumulate in the body.
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