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EC number: 228-055-8 | CAS number: 6104-30-9
LD50 > 10000 mg/kg bw (rat, males and females); BASF AG, 1967
LD50 > 2000 mg/kg bw (rat, male and female); BASF SE, 2008
Results are given as dead animals/total number of animals at this dose
at 24 h, 48 h and 7 days after dosing:
800 mg/kg bw: 0/10, 0/10, 0/10
1000 mg/kg bw: 0/10, 0/10, 0/10
1600 mg/kg bw: 0/10, 0/10, 0/10
3200 mg/kg bw: 0/10, 0/10, 0/10
6400 mg/kg bw: 0/10, 0/10, 0/10
10000 mg/kg bw: 0/10, 0/10, 0/10
Acute toxicity: oral
There is no study available, which is performed according to the current guideline. Nevertheless the study with rats (no data on strain, only 7 days post observation) is considered of sufficient and good quality to allow the evaluation of this endpoint. The LD50 in rats (5 animals/sex/dose) was > 10 000 mg/kg bw (IBDU, purity 90 – 96 %). The only clinical symptom noted was tachypnoea and piloerection at concentrations of 3200 mg/kg bw and higher. Doses of 800, 1000, 1600, 3200, 6400 and 10000 mg/kg bw were tested (BASF AG, 1967).
Acute toxicity: inhalation
The results from an inhalation risk test (with outdated methodology and lack of proper analytical verification of the test atmosphere concentration), where the rats were exposed to the dusty parts (predominant size range of 2 -20 µm) of the test substance for 8 hours at a mean nominal concentration of 2.6 mg/l indicated, that the test substance is not toxic by the inhalation route as no deaths occurred and no clinical signs were noted.
Acute toxicity: dermal
A GLP dermal toxicity study was conducted according to OECD guideline 402 with rats (Wistar strain, 14 days of observation). The dermal LD50 in rats (5 animals/sex) was > 2000 mg/kg bw (IBDU, purity 90.3%). There were no unusual observations of any kind at the limit dose of 2000 mg/kg bw (BASF AG, 2008).
No classification and labeling is required, as the oral LD50 was greater than 10000 mg/kg and the dermal LD50 was greater than 2000 mg/kg with no mortality observed in both studies.
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