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Dissociation constant

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Endpoint:
dissociation constant
Data waiving:
study technically not feasible
Justification for data waiving:
the study does not need to be conducted because the substance has no ionic structure
Guideline:
other:
GLP compliance:
no
Dissociating properties:
no
Endpoint:
dissociation constant
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically recognized software
Qualifier:
no guideline followed
GLP compliance:
no
Dissociating properties:
not determined
No.:
#1
pKa:
12.55
Temp.:
25 °C
Endpoint:
dissociation constant
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically recognized software
Qualifier:
no guideline followed
GLP compliance:
no
Dissociating properties:
no

pKa = 15.71 for the reaction:

R-NH2 --> R-NH(-) + H(+)

pKa = 13.94 for the reaction:

R1-NH-R2 --> R1-N-R2(-) + H(+)

Description of key information

not applicable

Key value for chemical safety assessment

Additional information

The substance is not ionic in nature.