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EC number: 214-968-9 | CAS number: 1229-55-6
Table 1: Ocular reaction data
Prior to instillation
24 (± 2) hours
48 (± 2) hours
72 (± 2) hours
No of animals
A x B x 5
A x 5
(A + B+ C) x 2
Total 1 +2 +3
Reaction to fluorescein
An eye irritation study was performed on 6 (3/sex) New Zealand White Albino rabbits to assess the irritation potential of Solvent Red 1.
0.1 g of neat Solvent Red 1 was instilled into the eyes of rabbits and the effects were observed. The treated eye of each animal was examined for ocular irritation and lesions at 24, 48 and 72 hours (+2 hours at each interval). The treated eyes were evaluated on days 7, 14, and 21 if irritation persisted. No mortality and clinical signs of toxicity were observed in treated rabbits. Redness (grades 1 through 3), chemosis (grades I and 2), discharge (grades 1 and 2) and iritis (grade 1) were observed. Blistering of the conjunctivae were observed.Blistering of the conjunctivae was noted for all animals. Two animals also exhibited opacities and positive fluorescein staining. All animals were considered to have exhibited a positive response to Solvent Red 1.
The mean irritation score after 72 hours was 0.7
Hence, Solvent Red 1 can be considered to be irritating to New Zealand White rabbit eyes.
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