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EC number: 226-749-5 | CAS number: 5462-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 16 Jun 2008 to 25 Jul 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: repeated insult patch test
- Short description of test conditions: During the induction phase 0.3 mL of test material was applied to a Webril/ adhesive patch (25 mm Hill Top Chamber system), which was applied occlusively on Mondays, Wednesdays and Fridays. The test side (left site of the back) was wiped with a dry Kimwipe prior to patching. The patches were removed after 24 hours and no test material was applied for 24 hours or 48 hours (after the Friday application). In total a series of 9 induction patches were completed over a period of approximately 3 weeks. In the rest period, approximately 2 weeks, no test material was applied. During the challenge phase, the original induction sites were observed. The virgin right back site was usually used for the challenge phase. After 24 hours the patches were removed and the induction and challenge site were observed. Additional observations were made after 48, 72 and 96 hours.
-Scoring system: the sites were scored using the modified scoring scale of the international contact dermatitis research group system (1986) - GLP compliance:
- no
Test material
- Reference substance name:
- 3-(p-methoxyphenyl)-2-methylpropionaldehyde
- EC Number:
- 226-749-5
- EC Name:
- 3-(p-methoxyphenyl)-2-methylpropionaldehyde
- Cas Number:
- 5462-06-6
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 3-(4-methoxyphenyl)-2-methylpropanal
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- confirmed and informed consent free of coercion received
- Subjects:
- - Number of subjects exposed: 126
- Sex: male (42) and female (84)
- number of subjects completed the test: 104 (33 male and 71 female)
- Age: 18 to 68 - Clinical history:
- - Did not exhibit any dermatological or other medical or physical condition which would preclude topical application.
- Not known pregnant nor nursing.
- An appropriate clearance period had elapsed since a subject was patched on a repeated insult patch test or a photo allergy test before being used in this study. - Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST USED:
repeated insult patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
- Description of patch: 25 mm Hill Top Chamber System
- Vehicle / solvent: no
- Concentrations: pure substance
- Volume applied: 0.3 mL
- Testing/scoring schedule: after 24 or 48 hours (induction phase) and 24, 48, 72 and 96 hours (challenge phase)
- Removal of test substance: Patches were removed by technicians, except at Saturdays when the subjects removed the patches themselves, 24 hours after start of exposure.
- A series of nine (9) induction patches were completed over a period of approximately three weeks.
- Canthoxal concentration in the solution is 5%.
EXAMINATIONS
- Grading/Scoring system: modified scoring scale of the international contact dermatitis research group system (1986)
Results and discussion
- Results of examinations:
- 0/104 subjects responded to the treatment
Applicant's summary and conclusion
- Conclusions:
- Application of 0.3 mL with 5% test substance was not sensitising under the conditions of the test.
- Executive summary:
The basic schedule was kept in the induction phase every Monday, Wednesday and Friday till 9 applications had been made in approximately 3 weeks. The test concentration used was 5%. During the induction patches were placed at the left side of the back. Technicians removed the patches 24 hours after application, except for Saturdays on which the patients removed the patches themselves. After removal 24 hours without treatment were conducted, except for the 48 hours treatment free period after the Friday application. After two weeks a challenge patch was applied to the virgin right side of the back and removed after 24 hours. Reactions to the challenge were assessed after 24, 48, 72 and 96 hours. None of the 104 subjects tested was sensitized by the sample. It was therefore concluded that the test substance is not sensitizing.
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