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EC number: 202-401-8 | CAS number: 95-23-8
Aminolon TTR was tested for mutagenicity with the strains TA 100, TA 1535, TA1537, TA 1538, TA 98 of Salmonella typhimurium and Escherichia coli WP2uvrA.
The mutagenicity studies were conducted in the absence and in the presence of a metabolizing system derived from rat liver homogenate. A dose range of 7 different doses from 4 µg/plate to 10 000 µg/plate was used.
Control plates without mutagen showed that the number of, spontaneous revertant colonies was similar to that described in the literature. All the positive control compounds gave the expected increase in the number of revertant colonies.
Toxicity: The test compound proved to be not toxic to the bacterial strains. 10 000 µg/plate was chosen as top dose level for the mutagenicity study.
Mutagenicity: In the absence of the metabolic activation system the test compound did not show a dose dependent increase in the number of revertants in any of the bacterial strains. Also in the presence of a metabolic activation system, treatment of the cells with Aminolon TTR did not result in relevant increases in the number of revertant colonies.
Summarizing, it can be stated that Aminolon TTR is not mutagenic in these bacterial test systems neither with nor without exogenous metabolic activation at the dose levels investigated.
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