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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
no
GLP compliance:
yes
Test type:
acute toxic class method

Test material

1
Chemical structure
Reference substance name:
Dichlorotricyclo[8.2.2.24,7]hexadeca-1(12),4,6,10,13,15-hexaene, mixed isomers
EC Number:
249-236-8
EC Name:
Dichlorotricyclo[8.2.2.24,7]hexadeca-1(12),4,6,10,13,15-hexaene, mixed isomers
Cas Number:
28804-46-8
Molecular formula:
C16H14Cl2
IUPAC Name:
Unknown constituents
Test material form:
solid: granular

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
6 females/2000 mg/kg bw
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Sex:
female
Dose descriptor:
LD50 cut-off
Effect level:
5 000 mg/kg bw
Mortality:
No mortality was observed in rats (set I and II) treated with 2000 mg DPX-C (Di-Cloro-Di-p-Xililene)/kg body weight.
Clinical signs:
No clinical sign was observed in all the rats treated with 2000 mg DPX-C (Di-Cloro-Di-p-Xililene)/kg body weight.
Body weight:
Normal gain in body weight was observed in all the surviving rats.
Gross pathology:
External
External examination of terminally sacrificed rats did not reveal any abnormality.
Internal
Visceral examination of terminally sacrificed rats did not reveal any abnormality.
In absence of any pathological lesion in terminally sacrificed rats, it is concluded that the test item did not produce any treatment related effect at the dose level used in the present study.

Applicant's summary and conclusion

Interpretation of results:
other:
Remarks:
Category 5 or Unclassified (GHS 2015)
Conclusions:
Based on the results of this study, an indication of the classification for DPX-C (Di-Cloro-Di-p-Xililene) is as follows: Globally Harmonized System of Classification and Labelling og Chemicals (GHS 2015): Category 5 or Unclassified.
Executive summary:

The acute oral toxicity ofDPX-C (Di-Cloro-Di-p-Xililene)was investigated using the acute toxic class method. Female Wistar rats at dosing were given a single oral dose ofDPX-C (Di-Cloro-Di-p-Xililene). The test item was administered in corn oil, following overnight fasting, at dose of 2000 mg/kg body weight andanimalswere observed for 14 days.

There were no treatment-related mortality, clinical sign and changes in body weight or necropsy findings observed.

The acute oral median lethal dose (LD50cut-off value) of DPX-C (Di-Cloro-Di-p-Xililene)in Wistar rats was found to be 5000 mg/kg body weight.

Based on the results of this study, an indication of the classification forDPX-C (Di-Cloro-Di-p-Xililene)isas follows:

Globally Harmonized System of Classification and Labelling of Chemicals (GHS 2015): Category 5 or Unclassified.

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