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EC number: - | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
Constituent 1
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- > 5.7
- Temp.:
- 20 °C
- pH:
- 7
Applicant's summary and conclusion
- Conclusions:
- The test item Sa 163 elutes after 6.2 minutes, the reference item triphenylamine after 3.5 minutes.
Due to the principle of the HPLC method, reference items will elute the later, the higher the log Pow value is. In conclusion, the test item
exhibits a log POW value significantly higher than the reference item.
The reference item triphenylamine is listed in the EU test procedure with the second highest log Pow value (5.7). Furthermore, the test
procedure is only applicable within log Pow values from - 2 to +6.
Thus, based on the preliminary tests, the following result can be reported:
Log Pow(Sa 163) > 5.7
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