Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-765-0 | CAS number: 1660-95-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- from 1989-12-27 to 1990-02-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No indication on the purity of the substance
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- To determine the irritation potential of the test article when applied dermally. This study was designed to comply with the FHSA standards set forth by 16 CFR 1500.41.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tetraisopropyl methylenebisphosphonate
- EC Number:
- 216-765-0
- EC Name:
- Tetraisopropyl methylenebisphosphonate
- Cas Number:
- 1660-95-3
- Molecular formula:
- C13H30O6P2
- IUPAC Name:
- tetraisopropyl methylenebis(phosphonate)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals
- Age at study initiation: No data
- Weight at study initiation: 2.0 -2.5 kg
- Housing: The animals were housed 2/cage in suspended wire mesh cages. Bedding was placed beneath the cages and changed twice/week.
- Diet (e.g. ad libitum): Fresh Purina Rabbit Chow (Diet #5321)
- Water (e.g. ad libitum): yes
- Acclimation period: At lest one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Controled but no data available
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: From 1990-01-02 to 1990-01-05
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped, abraded on left side and intact on right side
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL /site - Duration of treatment / exposure:
- 24 hour oclusive exposure
- Observation period:
- 72 hours
- Number of animals:
- 6 (3 males and 3 females)
- Details on study design:
- TEST SITE
Prior to application of the test article, the back and sides of each animal were clipped free of hair. The left side of each animal was abraded with a bent tip needle. Three abrasions, approximately 2-3 cm apart, extending the length of the exposure site were made. The abrasions were sufficiently deep to penetrate the stratum corneum, but not deep enough to produce bleeding. The right side of each animal remained intact.
EXPERIMENTAL DESIGN
The test article was used as received and dosed by volume, 0.5 ml/site, for a total dose of 1.0 ml/rabbit. The test article was applied to two areas, 1 intact and 1 abraded, on the prepared site, on the back of each of six rabbits.
The treated sites were covered with 2.5 cm square gauze patches which were secured with adhesive tape. The torso was wrapped with plastic which was secured with adhesive tape. The sites were occluded for 24 hours at which time the patches were removed.
TYPE AND FREQUENCY OF OBSERVATIONS
Animals were observed for skin reactions at 24 and 72 hours after application of the test article. Erythema and edema were scored according to the numerical Draize technique. Body weights were recorded pretest. Additional signs were described.
The general health of the animals was monitored at each observation time.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24h and 72h
- Score:
- 1.17
- Max. score:
- 1.17
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h and 72h
- Score:
- 0.75
- Max. score:
- 1.17
- Reversibility:
- no data
- Remarks on result:
- other: Intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h and 72h
- Score:
- 0.835
- Max. score:
- 1.17
- Reversibility:
- no data
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h and 72h
- Score:
- 0.335
- Max. score:
- 0.67
- Reversibility:
- no data
- Remarks on result:
- other: Intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h and 72 h
- Score:
- 0.42
- Max. score:
- 0.67
- Reversibility:
- no data
- Remarks on result:
- other: Abraded skin
Any other information on results incl. tables
Individual scores
Animal number |
C7859 |
C7860 |
C7861 |
C7808 |
C7813 |
C7814 |
Mean Scores |
|
Pretest body weight (kg) |
2.4 |
2.5 |
2.0 |
2.3 |
2.0 |
2.0 |
|
|
Erythema & eschar formation |
||||||||
Intact Skin |
24h |
1 |
1 |
1 |
2 |
1 |
1 |
1.17 |
72h |
0 |
0 |
0 |
1 |
0 |
1 |
0.33 |
|
Abraded skin |
24h |
1 |
1 |
1 |
2 |
1 |
1 |
1.17 |
72h |
1 |
0 |
0 |
1 |
0 |
1 |
0.50 |
|
Edema |
||||||||
Intact skin |
24h |
2 |
0 |
1 |
0 |
0 |
1 |
0.67 |
72h |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Abraded skin |
24h |
2 |
0 |
1 |
0 |
0 |
1 |
0.67 |
72h |
1 |
0 |
0 |
0 |
0 |
0 |
0.17 |
|
Sum of mean score |
4.68 |
|||||||
Primary dermal irritation index = sum of mean score /4 |
1.17 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance was not considered to be irritant.
- Executive summary:
The dermal irritation of TIPMDP was tested on 6 New Zealand Albino rabbits in a primary dermal irritation following the standards set forth by FHSA, 16 CFR 1500.3(c)(4). 0.5 ml of the test substance was applied to 1 intact and 1 abraded site on the clipped back for a total dose of 1.0 ml/rabbit. The sites were occluded for 24 hours. The skin reactions were evaluated by the Draize technique at 24 and 72 hours after dosing. Body weights were recorded pretest. The Primary Irritation Index was calculated.
Erythema , slight to well defined at 24 hours, was absent to slight at 72 hours. Edema, absent to well defined at 24 hours, was absent at 72 hours. Abnormal systemic signs of diarrhea and few feces were noted during the observation periods. The substance was not found to be irritating to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
