Registration Dossier
Registration Dossier
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EC number: 254-296-3 | CAS number: 39108-47-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-butyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxonicotinonitrile
- EC Number:
- 254-296-3
- EC Name:
- 1-butyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxonicotinonitrile
- Cas Number:
- 39108-47-9
- Molecular formula:
- C11H14N2O2
- IUPAC Name:
- 1-butyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
- Details on test material:
- Name of the test substance used in the study report: N-Butyl-2-hydroxy-3-cyan-4-methylpyridon(6)
solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- A standardized animal laboratory diet was used.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- about 1 g of a 50% aqueous preparation
- Duration of treatment / exposure:
- 20 hours
- Observation period:
- 8 d
- Number of animals:
- 2
- Details on study design:
- Application area: 2.5 x 2.5 cm
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 20 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: light-green substance residues
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 20 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: light-green substance residues
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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