Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 254-296-3 | CAS number: 39108-47-9
Endpoint summary
Administrative data
Description of key information
Not readily biodegradable (by OECD criteria).
Additional information
The biodegradation potential of the read-across substance 1-Ethyl-2-hydroxy-3-cyan-4-methylpyridon-6 (CAS 28141-13-1) in water was determined in a screening study according to OECD TG 301A (DOC Die Away Test) and in compliance with GLP criteria (BASF, 1999). In this study 90 mg/L test substance (equivalent to 20 mg/L DOC) was inoculated with non-adapted activated sludge from laboratory wastewater plants treating municipal sewage for 28 days under aerobic conditions. During the incubation period the degree of biodegradation is determined as removal of dissolved organic carbon (DOC). Based on DOC measurements it was determined that after the 28-day incubation period <10% of the substance was biodegraded. Based on these findings, ethylpyridon is assessed to be not readily biodegradable. Increased alkyl-chain length on cyclic substances is generally associated with decreased biodegradation potential of such a substance (OECD, 1993*). Therefore, it may be considered likely that the conclusion of non-ready biodegradation applies also to the target substance 1-butyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxonicotinonitrile.
* OECD (1993). Environment Monograph No. 68; Structure-Activity Relationships for Biodegradation. OECD/GD(93)126; Paris
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
