Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-244-1 | CAS number: 13254-34-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Method in Federal Register 38(187)1500.41, S.27029,1973.
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP introduction
Test material
- Reference substance name:
- 2,6-dimethylheptan-2-ol
- EC Number:
- 236-244-1
- EC Name:
- 2,6-dimethylheptan-2-ol
- Cas Number:
- 13254-34-7
- Molecular formula:
- C9H20O
- IUPAC Name:
- 2,6-dimethylheptan-2-ol
- Reference substance name:
- Unknown impurities
- Molecular formula:
- not applicable
- IUPAC Name:
- Unknown impurities
- Test material form:
- liquid
Constituent 1
impurity 1
- Specific details on test material used for the study:
- Product: 2,6-Dimethylheptanol -2 (liquid)
Substance No.: 77/278
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Details on study design:
- Primary eye irritation was measured in 6 rabbits. Readings at 24, 48 & 72 hrs and 8 days.
Results and discussion
In vivo
Results
- Remarks on result:
- probability of moderate irritation
- Irritant / corrosive response data:
- Primary irritation index: 536 / 18 = 29.8
The pathological findings on the eye and the irritations on the mucous membrane were not reversible within 8 days. Based on the findings the substance must be considered to be moderately irritant.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Based on the findings the substance must be considered to be moderately irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
