Registration Dossier
Registration Dossier
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EC number: 236-244-1 | CAS number: 13254-34-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment: Non-GLP study; no data about purity and no certificate of analysis of the test substance; no details on age, gender, weight and strain of rats and housing conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- Standard acute method (limit test)
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,6-dimethylheptan-2-ol
- EC Number:
- 236-244-1
- EC Name:
- 2,6-dimethylheptan-2-ol
- Cas Number:
- 13254-34-7
- Molecular formula:
- C9H20O
- IUPAC Name:
- 2,6-dimethylheptan-2-ol
- Reference substance name:
- Unknown impurities
- Molecular formula:
- not applicable
- IUPAC Name:
- Unknown impurities
- Test material form:
- liquid
Constituent 1
impurity 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Dimetol
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- Total no. of animals = 10
- Control animals:
- no
- Details on study design:
- - Animals were observed for mortality and clinical signs of toxicity for 14 days.
- Necropsy performed: Yes
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animals died
- Clinical signs:
- other: Skin irritation observed during acute dermal toxicity study: slight redness - 2/10 moderate redness - 8/10 sllight edema - 1/10 moderate edema - 9/10
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 for Dimetol is higher than 5000 mg/kg bw in rabbits therefore it is not classified according to the Directive 67/548/EEC and the CLP Regulation.
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