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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic data given, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Principles of method if other than guideline:
None
GLP compliance:
no
Test type:
fixed dose procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexasodium 2,2'-[vinylenebis[(3-sulphonato-4,1-phenylene)imino[6-morpholino-1,3,5-triazine-4,2-diyl]imino]]bis(benzene-1,4-disulphonate)
EC Number:
257-827-7
EC Name:
Hexasodium 2,2'-[vinylenebis[(3-sulphonato-4,1-phenylene)imino[6-morpholino-1,3,5-triazine-4,2-diyl]imino]]bis(benzene-1,4-disulphonate)
Cas Number:
52301-70-9
Molecular formula:
C40H40N12O20S6.6Na
IUPAC Name:
hexasodium 2,2'-[vinylenebis[(3-sulphonato-4,1-phenylene)imino[6-morpholino-1,3,5-triazine-4,2-diyl]imino]]bis(benzene-1,4-disulphonate)
Test material form:
solid: particulate/powder

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
Kaninchen: Gelbsilber
Tierzahl, Sex/Dosis: 3M 3F
Tierzahl pro Käfig: 1
Tierhaltung: konventionell, klimatisierter Raum: Temperatur 23+2°C, relative Luftfeuchtigkeit 55+/- 5%, 14 Lichtstunden/Tag
Futter: Nafag Würfel Nr. 84
Applikation: Enthaaren der Rückenhaut durch Scheren.
Einmalige Applikation auf intakte Haut. Occlusiv-Verband (Methode
nach Draize) während 24 Stunden.
Abwaschen der Applikationsfläche mit lauwarmem Wasser und Schwamm.
Fläche: 200 - 300cm2
Volumen: 2.5 ml/kg
Beobachtungszeit: 8 Tage
200-300 cm2
2,5 ml/kg
8 Tage

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
None
Duration of exposure:
None
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
3 M and 3 F
Control animals:
not specified
Details on study design:
None
Statistics:
None

Results and discussion

Preliminary study:
None
Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
None
Clinical signs:
other: 2000 mg/kg: 6/6: day 1-8: no symptoms related to resorption 24 h; 4/6: Erythema 2.-6. Tag: 6/6: no observations 7.+8. Tag: 1/6: scaling
Gross pathology:
None
Other findings:
None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
other: Not classified as toxic according to the CLP Regulation (EC) No.1272/2008
Conclusions:
The acute dermal LD50 of the test substance the substance was found to be >2000 mg/kg bw.
Executive summary:

The acute dermal toxicity of the substance was performed on rabbits. However, no mortality was observed throughout the observation period. Hence, the acute dermal LD50 of the test substance was found to be >2000 mg/kg bw.