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Ecotoxicological information

Toxicity to microorganisms

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Link to relevant study record(s)

Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Qualifier:
according to guideline
Guideline:
other: Method B-10 (Method used at Ciba Geigy).
Deviations:
not specified
GLP compliance:
no
Analytical monitoring:
no
Details on sampling:
No data
Vehicle:
not specified
Details on test solutions:
No data
Test organisms (species):
activated sludge
Details on inoculum:
None
Test type:
not specified
Water media type:
freshwater
Limit test:
no
Total exposure duration:
12 h
Remarks on exposure duration:
exposure duration 12-24 hours
Post exposure observation period:
Not applicable.
Hardness:
No data
Test temperature:
None
pH:
No data
Dissolved oxygen:
Not applicable
Salinity:
Not applicable
Nominal and measured concentrations:
None
Details on test conditions:
No data
Reference substance (positive control):
no
Key result
Duration:
12 h
Dose descriptor:
other: KST
Effect conc.:
> 300 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: exposure duration 12-24 hours
Details on results:
None
Results with reference substance (positive control):
Not applicable
Reported statistics and error estimates:
None
Validity criteria fulfilled:
not specified
Conclusions:
The KST for the substance was found to be greater than 300 mg/L.
Executive summary:

The toxicity to acivated sludge for the substance was found to be greater than 300 mg/L.

Description of key information

In a study carried out to determine toxicity to activated sludge of the test substance, the IC50 was found to be >300 mg/L after 12 hours of exposure. Similarly, in another supporting study, the IC50 to activated sludge was again >300 mg/l. Growth inhibition was the basis for effect in both studies.

Key value for chemical safety assessment

EC50 for microorganisms:
300 mg/L

Additional information