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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
not specified
GLP compliance:
yes
Analytical monitoring:
not specified
Details on sampling:
None
Vehicle:
yes
Details on test solutions:
Control: 0 mg/L
Test (1000 mg/L): 1000 mg/L
Test organisms (species):
Daphnia magna
Test type:
not specified
Water media type:
freshwater
Total exposure duration:
48 h
Post exposure observation period:
None
Hardness:
None
Test temperature:
20 °C
pH:
8.0 - 8.1
Dissolved oxygen:
99 %
Salinity:
None
Nominal and measured concentrations:
Control: 0 mg/L
Test: 1000 mg/L
Details on test conditions:
None
Duration:
48 h
Dose descriptor:
EC0
Effect conc.:
> 1 000 mg/L
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 1 000 mg/L
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
> 1 000 mg/L
Details on results:
For each control and test sample concentration 10 daphnids were included. The number of immobilized daphnids and % immobility noted to be 0.
Results with reference substance (positive control):
None
Reported statistics and error estimates:
None

Immobilization of Daphnia: Number of immobilized Daphnia after 24 and 48 hours

Nominal Conc. Of test material (mg/l) No. of Daphnia tested No. of immobilixzed Daphnia after: % of immobilized Daphnia after:
24 h 48 h 24 h 48 h
Control 5 0 0 0 0
5 0 0
Solvent control 5 0 0 0 0
5 0 0
Validity criteria fulfilled:
yes
Conclusions:
EC0: 1000 mg/L
EC50: >1000 mg/L
EC100: >1000 mg/L
Executive summary:

The acute toxicity of the substance to Daphnia magna was determined in a 48-hour static test according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). In the control and in all test concentrations no immobilization of the daphnids were observed after 48 hours. The EC50 values is greater than 1000 mg /L.

Description of key information

The acute toxicity of the test item to Daphnia magna was determined in a 48-hour static test according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). Daphnids were exposed to the substance at 1000 mg/l. In the control and in all test concentrations no immobilization of the daphnids has been observed after 48 hours of substance exposure. The EC50 value therefore is set to be greater than 1000 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
1 000 mg/L

Additional information