4-chlorobenzophenone

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Remarks:

Experimental data of read across substances

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data for the target chemical is summarized based on the read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

no guideline available

Principles of method if other than guideline:

WoE report is based on two short term toxicity to fish studies as-
WoE 2 and WoE 3.

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: WoE 2- Oryzias latipes, WoE 3- Pimephales promelas

Details on test organisms:

Common Name: WoE 2: Japanese rice fish, WoE 3: Fathead minnow

Test type:

static

Water media type:

freshwater

Total exposure duration:

96 h

Reference substance (positive control):

not required

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 1.52 - < 3.8 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: Other details not known

Key result

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

0.72 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: Other details not known

Key result

Duration:

96 h

Dose descriptor:

LOEC

Effect conc.:

1.05 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: Other details not known

Details on results:

1) Results after 24-hour exposure: - LC50: > 5.50 mg/L, - NOEC: 1.43 mg/L, - LOEC : 2.00 mg/L.

2) Results after 48-hour exposure: - LC50 : 4.60 mg/L (semi-log graph), - NOEC : 1.43 mg/L, - LOEC : 2.00 mg/L.

3) Results after 72-hour exposure: LC50 : 4.60 mg/L (semi-log graph), NOEC : 1.43 mg/L, - LOEC : 2.00 mg/L.

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, based on mortality effect the 96 hr NOEC, LOEC and LC50 value was determined to be 0.72, 1.05 and > 1.52 to < 3.8 mg/l respectively.

Executive summary:

Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on fishes. The studies are as mentioned below:

 

The first study of toxicity to fishes was carried out according to The Notice on the Test Method Concerning New Chemical Substances" guideline. The duration of test was 96 hr performed under static conditions. Oryzias latipes (Japanese rice fish) was taken as test organism. On the basis of mortality effect of test chemical on test organism Oryzias latipes (Japanese rice fish) the 24, 48, 72 hr NOEC and LOEC was determined to be  1.43 and 2.00 mg/L.  And the 24,48 and 72 hr LC50 value was determined to be > 5.50 mg/L and 4.60 mg/L (semi-log graph). On the basis of mortality effect of test chemical on test organism Oryzias latipes (Japanese rice fish) the 96 hr NOEC, LOEC and EC50 value was determined to be 0.72 , 1.05 and 3.8 mg/l respectively. As per the value of LC50 the test chemical was considered to be classified in category 'aquatic chronic 2' thus consider as toxic to fishes. 

 

The second study of short term toxicity to fish was carried. The duration of study was 96 hr and was performed under static conditions. Pimephales promelas (fathead minnow) was taken as test organism. On the basis of mortality effect of test chemical on test organism Pimephales promelas (fathead minnow) The 96 hr LC50 value was determined to be 1.52 mg/l with 95% CI of 0.96 to 2.41 mg/L. As per the value of LC50 the test chemical was considered to be classified in category 'aquatic chronic 2' thus consider as toxic to fishes. 

 

On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, based on mortality effect the 96 hr NOEC, LOEC and LC50 value was determined to be 0.72, 1.05 and > 1.52 to < 3.8 mg/l respectively. As per the value of LC50 the test chemical was considered to be classified in category 'aquatic chronic 2' thus consider as toxic to fishes. 

 

Description of key information

On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, based on mortality effect the 96 hr NOEC, LOEC and LC50 value was determined to be 0.72, 1.05 and > 1.52 to < 3.8 mg/l respectively.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Dose descriptor:

LC50

Effect concentration:

> 1.05 - < 3.8 mg/L

Additional information

Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on fishes. The studies are as mentioned below:

 

The first study of toxicity to fishes was carried out according to The Notice on the Test Method Concerning New Chemical Substances" guideline. The duration of test was 96 hr performed under static conditions. Oryzias latipes (Japanese rice fish) was taken as test organism. On the basis of mortality effect of test chemical on test organism Oryzias latipes (Japanese rice fish) the 24, 48, 72 hr NOEC and LOEC was determined to be  1.43 and 2.00 mg/L.  And the 24,48 and 72 hr LC50 value was determined to be > 5.50 mg/L and 4.60 mg/L (semi-log graph). On the basis of mortality effect of test chemical on test organism Oryzias latipes (Japanese rice fish) the 96 hr NOEC, LOEC and EC50 value was determined to be 0.72 , 1.05 and 3.8 mg/l respectively. 

 

The second study of short term toxicity to fish was carried. The duration of study was 96 hr and was performed under static conditions. Pimephales promelas (fathead minnow) was taken as test organism. On the basis of mortality effect of test chemical on test organism Pimephales promelas (fathead minnow) The 96 hr LC50 value was determined to be 1.52 mg/l with 95% CI of 0.96 to 2.41 mg/L.

 

On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, based on mortality effect the 96 hr NOEC, LOEC and LC50 value was determined to be 0.72, 1.05 and > 1.52 to < 3.8 mg/l respectively. As per the value of LC50 the test chemical was considered to be classified in category 'aquatic chronic 2' thus consider as toxic to fishes.