Registration Dossier

Administrative data

Description of key information

In a GLP-compliant guinea pig maximisation test, performed in accordance with OECD Test Guideline 406, twenty male guinea pigs exhibited no reactions indicative of skin sensitisation when treated with test material (Dow Corning 1997).

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

A guinea pig maximisation test was carried out according to OECD Test Guideline 406 and in compliance with GLP to assess the skin sensitising potential of the registered substance (Dow Corning 1997). All positive control animals exhibited reactions indicative of sensitisation at both the 24- and 48-hour readings. There were no skin reactions seen at either time point for any of the test or vehicle control animals. Under the conditions of this study, the test material was found not sensitising to the skin of male guinea pigs.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the available information on the lack of sensitisation potential of Silsesquioxanes, Phenyl, no classification is required in accordance with Regulation (EC) No 1272/2008.