α,α-dimethylphenethyl acetate

Skin sensitisation

Administrative data

Endpoint:

skin sensitisation: in vitro

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

publication

Title:

The Freund’s Complete Adjuvant Test and the Open Epicutaneous Test

Author:

Klecak, G.

Year:

1985

Bibliographic source:

Current Problems in Dermatology

Materials and methods

Principles of method if other than guideline:

In an open epicutaneous test in 6–8 guinea pigs, 0.1 ml of 100, 30, 10, 3, 1, or 0.3% 1,1-dimethyl-2-phenylethyl acetate was applied daily for 3 weeks with the site uncovered. Suitable vehicles were suggested as ethanol, acetone, water, petrolatum, and/or PEG. Following induction, the animals were challenged on days 21 and 35 with 0.025 ml of 4% 1,1-dimethyl-2-phenylethyl acetate. The sites were scored 24, 48 and 72 h after exposure.

GLP compliance:

not specified

Type of study:

open epicutaneous test

Test material

Test material information

Constituent 1

Reference substance name:

α,α-dimethylphenethyl acetate

EC Number:

205-781-3

EC Name:

α,α-dimethylphenethyl acetate

Cas Number:

151-05-3

Molecular formula:

C12H16O2

IUPAC Name:

1,1-dimethyl-2-phenylethyl acetate

Test material form:

solid

Results and discussion

In vitro / in chemico

Results

Remarks on result:

no indication of skin sensitisation

Remarks:

A challenge concentration of 4% 1,1-dimethyl-2-phenylethyl acetate did not cause any reactions. 1,1-Dimethyl-2-phenylethyl acetate was not sensitizing to guinea pigs