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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
review article or handbook
Title:
Diethyl ether [MAK Value Documentation, 1999]
Author:
The MAK Collection for Occupational Health and Safety
Year:
2012
Bibliographic source:
The MAK Collection for Occupational Health and Safety, 150–160, 2012

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation potential of diethyl ether in rabbits
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
Name of the test chemical: diethyl ether
Molecular Formula:C4H10O
Molecular Weight:74.12 g/mol
Substance Type: Organic
InChI:1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3
Physical State: Liquid
Specific details on test material used for the study:
Name of the test chemical: diethyl ether
Molecular Formula:C4H10O
Molecular Weight:74.12 g/mol
Substance Type: Organic
InChI:1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3
Physical State: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
liquid diethyl ether or its vapour (exact dose not specified)
Duration of treatment / exposure:
no data available
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Reversibility:
fully reversible
Remarks on result:
probability of mild irritation
Irritant / corrosive response data:
Mild reversible irritation of the rabbit eye was observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Mild reversible irritation of the rabbit eye was observed after exposure to liquid diethyl ether or its vapour. Since the effects were reversible in nature, diethyl ether can be considered not irritating to rabbit eyes.
Executive summary:

A study was performed to assess the ocular irritation potential of diethyl ether in rabbits.Rabbits were exposed to either liquid diethyl ether or its vapours and observed for signs of irritation (dose and duration not specified).Mild reversible irritation of the rabbit eye was observed after exposure to liquid diethyl ether or its vapour. Since the effects were reversible in nature, diethyl ether can be considered not irritating to rabbit eyes.