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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
for read across
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two toxicity study of microorganism for the test chemical :
2. Effective concentration was determined for Photobacterium phosphoreum using Microtox test.
3. Preliminary, determination of the inhibitory effect of wastewater containing substance on the Oxygen consumption of Pseudomonas putida.
Analytical monitoring:
not specified
Test organisms (species):
other: 2.Photobacterium phosphoreum 3.Pseudomonas putida
Test type:
static
Water media type:
freshwater
Total exposure duration:
30 min
Test temperature:
15 degree C
pH:
5-7
Duration:
5 min
Dose descriptor:
EC50
Effect conc.:
3.02 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
other: viability and sensitivity of the bacteria
Remarks on result:
other: no other information
Dose descriptor:
EC50
Effect conc.:
10 000 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks on result:
other: no other information
Conclusions:
The test chemical is not likely to be toxic to microorganism in the dose range of 3.02 to 10000 mg/l
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Photobacterium phosphoreum was test organism used to determined the toxicity of test material done by Microtox test method . The time period was 5 to 30 minute at 15 degree C and pH range from 5 to 9. After exposure, the 50% Effective concentration value for 1 test chemical to Photobacterium phosphoreum was determined to be 3.02 mg/l based on viability and sensitivity of bacteria.

In another study for structurally similar read across substance , Pseudomonas respiratory arrest test was carried out for the test material substance.The 50% Effective concentration (EC50) of the substance5is determined to be >10000 mg/L based on inhibitory effect on Oxygen consumption (respiration).

Description of key information

Toxicity to microorganisms:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Photobacterium phosphoreum was test organism used to determined the toxicity of test material done by Microtox test method . The time period was 5 to 30 minute at 15 degree C and pH range from 5 to 9. After exposure, the 50% Effective concentration value for 1 test chemical to Photobacterium phosphoreum was determined to be 3.02 mg/l based on viability and sensitivity of bacteria.

In another study for structurally similar read across substance , Pseudomonas respiratory arrest test was carried out for the test material substance.The 50% Effective concentration (EC50) of the substance5is determined to be >10000 mg/L based on inhibitory effect on Oxygen consumption (respiration).

Key value for chemical safety assessment

EC50 for microorganisms:
10 000 mg/L

Additional information

Toxicity to microorganisms:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Photobacterium phosphoreum was test organism used to determined the toxicity of test material done by Microtox test method . The time period was 5 to 30 minute at 15 degree C and pH range from 5 to 9. After exposure, the 50% Effective concentration value for 1 test chemical to Photobacterium phosphoreum was determined to be 3.02 mg/l based on viability and sensitivity of bacteria.

In another study for structurally similar read across substance , Pseudomonas respiratory arrest test was carried out for the test material substance.The 50% Effective concentration (EC50) of the substance5is determined to be >10000 mg/L based on inhibitory effect on Oxygen consumption (respiration).