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EC number: 233-265-8
CAS number: 10102-05-3
studied for acute toxicity after single oral administration in rats. The
test substance, available as an orange-brown powder, was given as an
aqueous solution at a dose of 200 mg/kg bw to groups of three male and
three female rats. A further group of three females received a dose of
2000 mg/kg bw.
higher dose one animal died within 24 hr and the remaining two animals
were sacrificed due to distress on day 2 after dosing. Lethargy and
hunched posture was evident within 2 hr of treatment. The two females
surviving until day 2 showed abdominal swelling, chromodacryorrhoea
around the snout and forelegs, yellow discolouration of the urine,
yellow staining of the genital region, piloerection and slow breathing.
At necropsy, all three females exhibited dark red or black
discolouration of the glandular mucosa. In two animals the stomach
contained blood, the glandular mucosa was perforated and the caecal
contents were dark red. Dark red foci were apparent in the thymus of one
posture and uncoordinated movements, lasting 2-3 days, and piloerection,
lasting from 4 hr to 1 day, were evident in females treated with 200
mg/kg bw. One female also had noisy breathing, lasting 4 hr. In males
dosed at 200 mg/kg bw the only clinical sign was hunched posture lasting
for 1 day. All animals survived the 14 day observation period and at
necropsy no abnormalities were evident in the rats dosed at 200 mg/kg bw.
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