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EC number: 811-432-1 | CAS number: 78433-08-6
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental Phase: 17 October 2018 to 31 October 2018. Report Issue:
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC column containing lipophilic and polar moieties.
- Details on study design: HPLC method:
- HPLC System : Agilent Technologies 1200, incorporating workstation and autosampler
Detector type : variable wavelength (VW)
Column : Waters XSelect CN 5μm (150 x 4.6 mm id)
Column temperature : 30 °C
pH of mobile phase : 6.5
Flow-rate : 1.0 mL/min
Injection volume : 10 μL
VW detector wavelength : 210 nm
PREPARATION OF SAMPLE SOLUTION
Test item (0.0225 g) was diluted to 100 mL with methanol, to give a concentration of 225 mg/L.
MOBILE PHASE
Type: Methanol: purified water (55:45 v/v)
DETEMINATION OF DEAD TIME
Method: The dead time was determined by measuring the retention time of a formamide (purity* 99.6%) of a 671 mg/L solution in mobile phase.
REFERENCE SUBSTANCES
Identity: Acetanilide, Phenol, Atrazine, Isoproturon, Triadimenol, Linuron, Naphthalene, Fenthion, α-Endosulfan, Diclofop-methyl, Phenanthrene, DDT. - Key result
- Type:
- Koc
- Value:
- > 430 000 dimensionless
- Temp.:
- 30 °C
- Key result
- Type:
- log Koc
- Value:
- > 5.53 dimensionless
- Temp.:
- 30 °C
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test item has been determined to be greater than 4.3 x 10^5, log10 Koc >5.63. The results classify the test item as being immobile.
- Executive summary:
Introduction
The Adsorption coefficient of the test item was determined using a HPLC screening method designed to be compatible with the following guidelines:
-
Method C.19 Adsorption Coefficient of
Commission Regulation (EC) No 440/2008 of 30 May 2008
- Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.
Conclusion
The adsorption coefficient of the test item has been determined to be greater than 4.3 x 105, log10 Koc >5.63. The results classify the test item as being immobile.
-
Method C.19 Adsorption Coefficient of
Commission Regulation (EC) No 440/2008 of 30 May 2008
Reference
The retention times, capacity factor and log10 Koc value determined for the sample are shown in the following table:
| Injection | Retention Time (min) |
Capcity Factor (K') |
Log10 K' | Log10 Koc |
| 1 | ≥ 31.696 | > 10.324 | > 1.014 | > 5.63 |
| 2 | ≥ 31.696 | > 10.324 | > 1.014 | > 5.63 |
Mean log10 Koc: >5.63
Adsorption coefficient: >4.3 x 105
Description of key information
Absorption Coefficient of the test substance by HPLC screening method.
Key value for chemical safety assessment
- Koc at 20 °C:
- 430 000
Additional information
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