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Toxicity to other aquatic organisms

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Endpoint:
toxicity to other aquatic vertebrates
Data waiving:
other justification
Justification for data waiving:
other:
Endpoint:
toxicity to other aquatic vertebrates
Type of information:
other: published data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Carbon disulphide (CAS number 75–15–0) is both reagents used in the manufacture of S-allyl O-pentyl dithiocarbonate. Therefore, Carbon disulphide (CAS number 75–15–0) need to be considered in the assessment of S-allyl O-pentyl dithiocarbonate.
Qualifier:
no guideline required
Principles of method if other than guideline:
Effects of different concentrations of carbon disulphide on the embryonic development of frog investigated.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Microhyla ornata
Details on test organisms:
Fresh, naturally fertilized eggs of the frog Microhyla ornata were obtained from a local, unpolluted pond. The jelly was removed with forceps and the eggs were transferred to aged tapwater. Eggs in early gastrulation (dorsal lip) were then used in experimentation as per the procedure described earlier (Ghate, 1980 & 1983 a). 50 Embryos per concentration expodes.
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
NR
Test temperature:
NR
pH:
NR
Dissolved oxygen:
NR
Salinity:
NR
Nominal and measured concentrations:
SOLVENT
NAME: Ethanol
COMMENT: 1 ML CS2 TO 50 ML ALCOHOL
Details on test conditions:
4 µL CS2 / 100 mL aged tapwater: no mortality / Development normal
8 µL CS2 / 100 mL aged tapwater: no mortality / Hatching delayed by few hours / Tadpoles showed slightly abnormal notochord
12 µL CS2 / 100 mL aged tapwater: no mortality / Hatching delayed 50% failed to hatch even at 96 hrs. / All were oedematic with wavy notochord
16 µL CS2 / 100 mL aged tapwater: 90% mortality in 24 hrs. / All dead in 48 hrs.
20 µL CS2 / 100 mL aged tapwater: 100% mortality in 24 hrs.
Reference substance (positive control):
not specified
Duration:
24 h
Dose descriptor:
LC100
Effect conc.:
126 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
The embryonic development of frogs was disturbed at a concentration of 126 mg CS2/L, with no hatching taking place (100% mortality) .

4 µL CS2 / 100 mL aged tapwater: no mortality / Development normal

8 µL CS2 / 100 mL aged tapwater: no mortality / Hatching delayed by few hours / Tadpoles showed slightly abnormal notochord

12 µL CS2 / 100 mL aged tapwater: no mortality / Hatching delayed 50% failed to hatch even at 96 hrs. / All were oedematic with wavy notochord

16 µL CS2 / 100 mL aged tapwater: 90% mortality in 24 hrs. / All dead in 48 hrs.

20 µL CS2 / 100 mL aged tapwater: 100% mortality in 24 hrs.

Validity criteria fulfilled:
not specified
Conclusions:
The embryonic development of frogs was disturbed at a concentration of 126 mg CS2/L, with no hatching taking place (100% mortality) .
Carbon disulphide (CAS number 75–15–0) is both reagents used in the manufacture of S-allyl O-pentyl dithiocarbonate. Therefore, Carbon disulphide (CAS number 75–15–0) need to be considered in the assessment of S-allyl O-pentyl dithiocarbonate.

Description of key information

Expert Judgement 

S-allyl O-pentyl dithiocarbonate and xanthate esters are used in the mining industry as flotation agents as a fine collector for minerals such as copper sulfate, lead, zinc, molybdenum and nickel. The S-allyl O-pentyl dithiocarbonate and xanthate esters is the best collector for metallic copper, molybdenite, and sulfidized base metal oxides.  The amount of S-allyl O-pentyl dithiocarbonate used is very small relative to the quantity of ore treated, being approximately 2 to 50 g/tonne of ore. The flotation process is fully automated. The process takes place in open tanks. However, the concentration of S-allyl O-pentyl dithiocarbonate in the flotation tank is low and, therefore, the release of Carbon monoxide; cardon dioxide; oxides of nitrogen; oxides of sulphur (includes sulphur di and tri oxides) would be expected to be low. Air monitoring data, although limited and of poor quality, indicate that the atmospheric levels of cardon dioxide; oxides are below 10 ppm in the flotation areas. The risk to workers during the flotation process is considered to be low. Due to the absence of chemical groups or other structural alerts this substance is not considered to exhibit an high hazard potential. The results suggest for S-allyl O-pentyl dithiocarbonatethat direct and indirect exposure of other aquatic organisms is unlikely. Therefore testing for Toxicity to other aquatic organisms does not need to be performed.  

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