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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authorized database

Data source

Reference
Reference Type:
other: authorized database
Title:
Acute oral toxicity of CAS no 97-56-3
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus A TOXNET Database

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study 2-methyl-4-[(2-methylphenyl)diazenyl]aniline in dog
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
2-methyl-4-[(2-methylphenyl)diazenyl]aniline
Cas Number:
97-56-3
Molecular formula:
C14H15N3
IUPAC Name:
2-methyl-4-[(2-methylphenyl)diazenyl]aniline
Details on test material:
c1(\N=N\c2cc(c(N)cc2)C)c(cccc1)C
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-methyl-4-[(2-methylphenyl)diazenyl]aniline
- Molecular formula (if other than submission substance): C14H15N3
- Molecular weight (if other than submission substance): 225.294 g/mole
- Substance type: Organic

Test animals

Species:
dog
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
300 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
300 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality was observed at 300 mg/kg bw in treated dog.
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
LD50 was considered to be 300 mg/kg bw when dog were treated with 2-methyl-4-[(2-methylphenyl)diazenyl]aniline orally.

Executive summary:

In acute oral toxicity study,dogs were treated with 2-methyl-4-[(2-methylphenyl)diazenyl]aniline in the concentration of 300 mg/kg bw. 50 % mortality was observed at 300 mg/kg bw in treated dog. Therefore,LD50 was considered to be300 mg/kg bw when dog were treated with 2-methyl-4-[(2-methylphenyl)diazenyl]aniline orally.